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Colorectal carcinoma: Ex vivo evaluation using q‐space imaging; Correlation with histopathologic findings
Author(s) -
Yamada Ichiro,
Hikishima Keigo,
Yoshino Norio,
Sakamoto Junichiro,
Miyasaka Naoyuki,
Yamauchi Shinichi,
Uetake Hiroyuki,
Yasuno Masamichi,
Saida Yukihisa,
Tateishi Ukihide,
Kobayashi Daisuke,
Eishi Yoshinobu
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26018
Subject(s) - medicine , effective diffusion coefficient , nuclear medicine , colorectal cancer , diffusion mri , lymph node , receiver operating characteristic , magnetic resonance imaging , spearman's rank correlation coefficient , flip angle , radiology , pathology , cancer , mathematics , statistics
Background Although the prognosis of colorectal carcinoma (CRC) patients depends on the histologic grade (HG) and lymph node metastasis (LNM), accurate preoperative assessment of these prognostic factors is often difficult. Purpose To assess the HG and extent of LNM by q‐space imaging (QSI) for preoperative diagnosis of CRC. Study Type Prospective. Specimen A total of 20 colorectal tissue samples containing adenocarcinomas and resected lymph nodes (LNs). Field Strength/Sequence QSI was performed with a 3T MRI system using a diffusion‐weighted echo‐planar imaging sequence: repetition time, 10,000 msec; echo time, 216 or 210 msec; field of view, 113 × 73.45 mm; matrix, 120 × 78; section thickness, 4 mm; and 11 b values ranging from 0 to 9000 s/mm 2 . Assessment The mean displacement (MDP; μm), zero‐displacement probability (ZDP; arbitrary unit [a.u.]), kurtosis (K; a.u.), and apparent diffusion coefficient (ADC) were analyzed by two observers and compared with histopathologic findings. Statistical Tests Spearman's rank correlation coefficient, Mann–Whitney U ‐test, and ROC curve analyses. Results For all 20 carcinomas, the MDP, ZDP, K, and ADC were 8.87 ± 0.37 μm, 82.0 ± 6.2 a.u., 74.3 ± 3.0 a.u., and 0.219 ± 0.040 × 10 −3 mm 2 /s, respectively. The MDP ( r = –0.768; P < 0.001), ZDP ( r = 0.768; P < 0.001), and K ( r = 0.785; P < 0.001) were significantly correlated with the HG of CRC, but not the ADC ( r = 0.088; P = 0.712). There were also significant differences in the MDP, ZDP, and K between metastatic and nonmetastatic LNs (all, P < 0.001), but not the ADC ( P = 0.082). In the HG of CRC and LNM, the area under the curve was significantly greater for MDP, ZDP, and K than for ADC. Data Conclusion QSI provides useful diagnostic information to assess the HG and extent of LNM in CRC. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1059–1068.