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Cardiac MR Characterization of left ventricular remodeling in a swine model of infarct followed by reperfusion
Author(s) -
Whitaker John,
Tschabrunn Cory M.,
Jang Jihye,
Leshem Eran,
O'Neill Mark,
Manning Warren J.,
Anter Elad,
Nezafat Reza
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26005
Subject(s) - medicine , cardiology , myocardial infarction , infarction , ischemia , ventricular remodeling , nuclear medicine
Background Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. Purpose We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia‐reperfusion‐mediated MI. Animal Model Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia‐reperfusion experimental model of MI. Field Strength/Sequences 1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post‐MI, including cine imaging, native and postcontrast T 1 , T 2 and dark‐blood late gadolinium enhanced (DB‐LGE) scar imaging. Assessment Regions of interest were selected on the parametric maps to assess native T 1 and T 2 in the infarct and in remote tissue. Volume of enhanced tissue, nonenhanced tissue, and gray zone were assessed from DB‐LGE imaging. Volumes, cardiac function, and strain were calculated from cine imaging. Statistical Tests Parameters estimated at more than two timepoints were compared with a one‐way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P < 0.05. Results All animals developed anteroseptal akinesia and hyperenhancement on DB‐LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days ( P = 0.008). Native T 1 of ischemic myocardium increased from 1173 ± 93 msec at 16 days to 1309 ± 97 msec at 62 days ( P < 0.001). Mean radial and circumferential strain rate magnitude in remote myocardium increased with time from the infarct ( P < 0.05). Date Conclusion In this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation. Level of Evidence : 2 Technical Efficacy : Stage 2 J. Magn. Reson. Imaging 2018;48:808–817.