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Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers
Author(s) -
Besa Cecilia,
Wagner Mathilde,
Lo Grace,
Gordic Sonja,
Chatterji Manjil,
Kennedy Paul,
Stueck Ashley,
Thung Swan,
Babb James,
Smith Andrew,
Taouli Bachir
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25911
Subject(s) - gadoxetic acid , magnetic resonance elastography , medicine , receiver operating characteristic , elastography , fibrosis , stage (stratigraphy) , magnetic resonance imaging , liver fibrosis , radiology , histopathology , pathology , gadolinium dtpa , ultrasound , biology , paleontology
Background Multiparametric magnetic resonance imaging (mpMRI) combining different techniques such as MR elastography (MRE) has emerged as a noninvasive approach to diagnose and stage liver fibrosis with high accuracy allowing for anatomical and functional information. Purpose To assess the diagnostic performance of mpMRI including qualitative and quantitative assessment of MRE, liver surface nodularity (LSN) measurement, hepatic enhancement ratios postgadoxetic acid, and serum markers (APRI, FIB‐4) for the detection of liver fibrosis. Study Type IRB‐approved retrospective. Subjects Eighty‐three adult patients. Field Strength/Sequence 1.5T and 3.0T MR systems. MRE and T 1 ‐weighted postgadoxetic acid sequences. Assessment Two independent observers analyzed qualitative color‐coded MRE maps on a scale of 0–3. Regions of interest were drawn to measure liver stiffness on MRE stiffness maps and on pre‐ and postcontrast T 1 ‐weighted images to measure hepatic enhancement ratios. Software was used to generate LSN measurements. Histopathology was used as the reference standard for diagnosis of liver fibrosis in all patients. Statistical Tests A multivariable logistic analysis was performed to identify independent predictors of liver fibrosis. Receiver operating characteristic (ROC) analysis evaluated the performance of each imaging technique for detection of fibrosis, in comparison with serum markers. Results Liver stiffness measured with MRE provided the strongest correlation with histopathologic fibrosis stage ( r = 0.74, P < 0.001), and the highest diagnostic performance for detection of stages F2‐F4, F3‐F4, and F4 (areas under the curve [AUCs] of 0.87, 0.91, and 0.89, respectively, P < 0.001) compared to other methods. Qualitative assessment of MRE maps showed fair to good accuracy for detection of fibrosis (AUC range 0.76–0.84). Multivariable logistic analysis identified liver stiffness and FIB‐4 as independent predictors of fibrosis with AUCs of 0.90 (F2‐F4), 0.93 (F3‐F4) and 0.92 (F4) when combined. Data Conclusion Liver stiffness measured with MRE showed the best performance for detection of liver fibrosis compared to LSN and gadoxetic acid uptake, with slight improvement when combined with FIB‐4. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1552–1561.