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Role of the combination of FA and T 2 * parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease
Author(s) -
Fang Yuan,
Zheng Tao,
Liu Lanxiang,
Gao Dawei,
Shi Qinglei,
Dong Yanchao,
Du Dan
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25900
Subject(s) - substantia nigra , medicine , analysis of variance , parkinson's disease , fractional anisotropy , nuclear medicine , therapeutic effect , repeated measures design , population , diffusion mri , urology , gastroenterology , magnetic resonance imaging , pathology , disease , radiology , statistics , mathematics , environmental health
Background Simple diffusion delivery (SDD) has attained good effects with only tiny amounts of drugs. Fractional anisotropy (FA) and relaxation timeT 2 *that indicate the integrity of fiber tracts and iron concentration within brain tissue were used to evaluate the therapeutic effect of SDD. Purpose To evaluate therapeutic effect of SDD in the Parkinson's disease (PD) rat model with FA andT 2 *parameters. Study Type Prospective case–control animal study. Population Thirty‐two male Sprague Dawley rats (eight normal, eight PD, eight SDD, and eight subcutaneous injection rats). Field Strength/Sequence Single‐shot spin echo echo‐planar imaging and fast low‐angle shot T 2 WI sequences at 3.0T. Assessment Parameters of FA andT 2 *on the treated side of the substantia nigra were measured to evaluate the therapeutic effect of SDD in a PD rat model. Statistical Tests The effects of time on FA andT 2 *values were analyzed by repeated measurement tests. A one‐way analysis of variance was conducted, followed by individual comparisons of the mean FA andT 2 *values at different timepoints. Results The FA values on the treated side of the substantia nigra in the SDD treatment group and subcutaneous injection treatment group were significantly higher at week 1 and lower at week 6 than that of the PD control group (SDD vs. PD, week 1, adjusted P = 0.012; subcutaneous vs. PD, week 1, adjusted P < 0.001; SDD vs. PD, week 6, adjusted P = 0.004; subcutaneous vs. PD, week 6, adjusted P = 0.024). TheT 2 *parameter in the SDD treatment group and subcutaneous injection treatment group was significantly higher than that in the PD control group at week 6 (SDD vs. PD, adjusted P = 0.032; subcutaneous vs. PD, adjusted P < 0.001). Data Conclusion The combination of FA andT 2 *parameters can potentially serve as a new effective evaluation method of the therapeutic effect of SDD. Level of Evidence: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2017.