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Reverse double inversion‐recovery: Improving motion robustness of cardiac T 2 ‐weighted dark‐blood turbo spin‐echo sequence
Author(s) -
Hu Chenxi,
Huber Steffen,
Latif Syed R.,
SantacanaLaffitte Guido,
Mojibian Hamid R.,
Baldassarre Lauren A.,
Peters Dana C.
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25886
Subject(s) - ventricle , cardiology , medicine , cardiac cycle , diastole , wilcoxon signed rank test , nuclear medicine , nuclear magnetic resonance , physics , blood pressure , mann–whitney u test
Background Cardiac dark‐blood turbo spin‐echo (TSE) imaging is sensitive to through‐plane motion, resulting in myocardial signal reduction. Purpose To propose and validate reverse double inversion‐recovery (RDIR)—a dark‐blood preparation with improved motion robustness for the cardiac dark‐blood TSE sequence. Study Type Prospective. Population Healthy volunteers ( n = 10) and patients ( n = 20). Field Strength 1.5T (healthy volunteers) and 3T (patients). Assessment Compared to double inversion recovery (DIR), RDIR swaps the two inversion pulses in time and places the slice‐selective 180° in late‐diastole of the previous cardiac cycle to minimize slice misregistration. RDIR and DIR were performed in the same left‐ventricular basal short‐axis slice. Healthy subjects were imaged with two preparation slice thicknesses, 110% and 200%, while patients were imaged using a 200% slice thickness only. Images were assessed quantitatively, by measuring the myocardial signal heterogeneity and the extent of dropout, and also qualitatively on a 5‐point scale. Statistical Tests Quantitative and qualitative data were assessed with Student's t ‐test and Wilcoxon signed‐rank test, respectively. Results In healthy subjects, RDIR with 110% slice thickness significantly reduced signal heterogeneity in both the left ventricle (LV) and right ventricle (RV) (LV: P = 0.006, RV: P < 0.0001) and the extent of RV dropout ( P < 0.0001), while RDIR with 200% slice thickness significantly reduced RV signal heterogeneity ( P = 0.001) and the extent of RV dropout ( P = 0.0002). In patients, RDIR significantly reduced RV myocardial signal heterogeneity (0.31 vs. 0.43; P = 0.003) and the extent of RV dropout (24% vs. 46%; P = 0.0005). LV signal heterogeneity exhibited a trend towards improvement with RDIR (0.12 vs. 0.16; P = 0.06). Qualitative evaluation showed a significant improvement of LV and RV visualization in RDIR compared to DIR (LV: P = 0.04, RV: P = 0.0007) and a significantly improved overall image quality ( P = 0.03). Data Conclusion RDIR TSE is less sensitive to through‐plane motion, potentiating increased clinical utility for black‐blood TSE. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1498–1508.