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Dynamic contrast‐enhanced MRI in orbital lymphoproliferative disorders: Effects of region of interest selection methods on time efficiency, measurement reproducibility, and diagnostic ability
Author(s) -
Qian Wen,
Xu XiaoQuan,
Hu Hao,
Su GuoYi,
Wu JiangFen,
Shi HaiBin,
Wu FeiYun
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25859
Subject(s) - region of interest , intraclass correlation , reproducibility , nuclear medicine , magnetic resonance imaging , receiver operating characteristic , medicine , radiology , mathematics , statistics
Background Previous studies indicated that dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) could serve as a useful biomarker for differentiating malignant from benign orbital lymphoproliferative disorders (OLPDs). Purpose To investigate the influence of different region of interest (ROI) selection methods on the measurements of DCE‐MRI parameters, and their diagnostic ability in discriminating malignant from benign OLPDs. Study Type Retrospective study. Population In all, 46 patients with OLPDs (22 benign and 24 malignant). Field Strength/Sequence 3.T DCE‐MRI using a 2D turbo fast low angle shot sequence postcontrast. Assessment DCE‐MRI data were analyzed using three different ROI selection methods, including whole‐tumor ROI (ROI WT ), single‐slice ROI (ROI SS ) and hot‐spot ROI (ROI HS ). Quantitative parameters (K trans , K ep , V e ) were calculated based on a modified Tofts model. Statistical Testing Analysis of variance test, intraclass correlation coefficient (ICC), Bland–Altman plots, independent t ‐test, and receiver operating characteristic curve analyses were used for statistical analyses. Results The time required for outlining ROI WT was significantly longer than ROI SS and ROI HS ( P < 0.001). The measurements of DCE‐MRI‐derived parameters based on ROI HS demonstrated lowest ICC, followed by ROI SS and ROI WT . Malignant OLPDs showed significantly higher K ep than benign mimics ( P < 0.001), while no significant differences were found on K trans (ROI WT , P = 0.535; ROI SS , P = 0.557; ROI HS , P = 0.400) and V e (ROI WT , P = 0.071; ROI SS , P = 0.079; ROI HS , P = 0.057). K ep ‐ROI WT showed the highest area under curve for differentiating malignant from benign OLPDs, followed by K ep ‐ROI SS , and Kep‐ROI HS ; however, the differences were not significant (ROI WT vs. ROI SS , P = 0.407; ROI WT vs. ROI HS , P = 0.363; ROI SS vs. ROI HS , P = 0.887). Data Conclusion ROI selection methods could have an influence on the measurements of DCE‐MRI parameters. Taking measurement time, reproducibility, and diagnostic ability into account, we suggest single‐slice ROI to be used for differentiating malignant from benign OLPDs in clinical practice. Level of Evidence : 3 Technical Efficacy : Stage 2 J. Magn. Reson. Imaging 2018;47:1298–1305.