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Lung Cancer: Short‐Term Reproducibility of Intravoxel Incoherent Motion Parameters and Apparent Diffusion Coefficient at 3T
Author(s) -
Jiang Jianqin,
Yin Jianbin,
Cui Lei,
Gu Xiaowen,
Cai Rongfang,
Gong Shenchu,
Xu Yiming,
Ma Hang,
Mao Jian
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25820
Subject(s) - reproducibility , intravoxel incoherent motion , intraclass correlation , medicine , nuclear medicine , effective diffusion coefficient , lung cancer , coefficient of variation , repeatability , diffusion mri , magnetic resonance imaging , radiology , pathology , mathematics , statistics
Purpose To prospectively evaluate the short‐term reproducibility of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) in lung cancer patients. Materials and Methods In all, 50 patients (50 lesions) underwent free‐breathing diffusion‐weighted imaging (DWI) (b = 0, 300, 800 s/mm 2 ) and IVIM (10 b‐values, 0–1000 s/mm 2 ) scans twice (0.5–1‐hour interval) at 3T. Regions of interests (ROIs) were drawn on ADC maps and IVIM images to derive the mean ADC value and IVIM parameters D, D*, and f. Intra‐ and interobserver, test–retest reproducibility were assessed with intraclass correlation coefficients (ICCs), within coefficient‐of‐variations (WCVs), and Bland–Altman analysis. The effects of type, size, and location of lung lesions were compared with WCVs. Results D and ADC showed good intraobserver reproducibility and interobserver agreement, while D* and f showed relatively larger variability (WCV 20.89–34.97%). The test–retest reproducibility of D and ADC were good (ICC 0.763–0.837; WCV 11.12–12.55%), while those of D* and f were relatively poor (ICC 0.604–0.842; WCV 36.54–72.62%). D and ADC had decreased reproducibility for lesions <2 cm (WCV 14.20%, 16.34%, respectively) and for lesions in the lower lung zones (WCV 16.52%, 14.78%, respectively). f had decreased reproducibility in central lung cancers (WCV 50.11%) and lesions >2 cm (WCV 42.64%). D* had even worse reproducibility in peripheral lung cancers (WCV 84.11%) and lesions in the lower lung zones (WCV 80.84%). Conclusion If the change in ADC, D, D*, and f values is less than ∼31%, 34%, 170%, and 130%, respectively, it may be caused by measurement error. The type, size, and location of lung lesions have an effect on measurement errors. Level of Evidence: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2018;47:1003–1012.

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