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Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) and T 2 mapping of talar osteochondral lesions: Indicators of clinical outcomes
Author(s) -
Rehnitz Christoph,
Kuni Benita,
Wuennemann Felix,
Chloridis Dimitrios,
Kirwadi Anand,
Burkholder Iris,
Kauczor HansUlrich,
Weber MarcAndré
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25731
Subject(s) - medicine , youden's j statistic , cutoff , magnetic resonance imaging , cartilage , ankle , gadolinium , nuclear medicine , receiver operating characteristic , orthopedic surgery , region of interest , radiology , surgery , anatomy , physics , materials science , quantum mechanics , metallurgy
Purpose To evaluate the utility of delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T 2 mapping in evaluation of type II osteochondral lesions (OCLs) of the talus and define cutoff values for identifying patients with good/poor clinical outcomes. Materials and Methods 28 patients (mean age, 42.3 years) underwent T 2 mapping and dGEMRIC at least 1.5 years (mean duration, 3.5 years) after microfracture ( n = 12) or conservative ( n = 16) treatment for type II OCL. Clinical outcomes were considered good with an American Orthopedic Foot and Ankle Society score ≥80. The T 1 / T 2 ‐values and indices of repair tissue (RT; cartilage above the OCL) were compared to those of the adjacent normal cartilage (NC) by region‐of‐interest analysis. The ability of the two methods to discriminate RT from NC was determined by area under the receiver operating characteristics curve (AUC) analysis. The Youden index was maximized for T 1 / T 2 measures for identifying cutoff values indicative of good/poor clinical outcomes. Results Repair tissue exhibited lower dGEMRIC values (629.83 vs. 738.51 msec) and higher T 2 values (62.07 vs. 40.69 msec) than NC ( P < 0.001). T 2 mapping exhibited greater AUC than dGEMRIC (0.88 vs. 0.69; P = 0.0398). All T 1 measures exhibited higher maximized Youden indices than the corresponding T 2 measures. The highest maximized Youden index for T 1difference was observed at a cutoff value of 84 msec (sensitivity, 78%; specificity, 83%). Conclusion While T 2 mapping is superior to dGEMRIC in discriminating RT, the latter better identifies good/poor clinical outcomes in patients with type II talar OCL. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1601–1610.