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Feasibility of gadoteric acid for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) at the wrist and knee and comparison with Gd‐DTPA
Author(s) -
Rehnitz Christoph,
Klaan Bastian,
Do Thuy,
Barié Alexander,
Kauczor HansUlrich,
Weber MarcAndré
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25688
Subject(s) - medicine , gadolinium , magnetic resonance imaging , nuclear medicine , wrist , confidence interval , gadolinium dtpa , intraclass correlation , radiology , chemistry , clinical psychology , organic chemistry , psychometrics
Purpose To assess the feasibility of gadoteric acid for delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd‐DTPA. Materials and Methods At 3T, dGEMRIC of the wrist was performed twice using a T 1 ‐weighted 3D‐volumetric interpolated breath‐hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd‐DTPA 3 weeks later. In addition, 24 patients with knee pain were examined using gadoteric acid ( n = 12; seven women; mean age 45.8 years) or Gd‐DTPA ( n = 12; four women; mean age 47.1 years). T 1 values, the relative decrease in T 1 , and the delta R1 were compared using t ‐tests. Interobserver agreement was assessed using the intraclass correlation (ICC) between two independent readers. Results At the wrist, there was no significant difference in delta R1 values (0.34 ± 0.10/s, 95% confidence interval [0.30;0.38]/s for gadoteric acid and 0.32 ± 0.09 [0.29;0.35]/s for Gd‐DTPA, P = 0.24) or the relative decrease in T 1 (0.25 ± 0.06 [0.29;0.35] msec for gadoteric acid and 0.24 ± 0.05 [0.22;0.27] msec for Gd‐DTPA, P = 0.35). High observer agreement was found at precontrast (ICC = 0.87, P < 0.001) and postcontrast (ICC = 0.89, P < 0.001). Similarly, at the knee, there was no significant difference in delta R1 (0.39 ± 0.18 [0.32;0.47]/s for gadoteric acid and 0.41 ± 0.09 [0.38;0.45]/s for Gd‐DTPA, P = 0.59) or the relative decrease in T 1 (0.30 ± 0.10 [0.26;0.34] msec for gadoteric acid and 0.33 ± 0.05 [0.30;0.35] msec for Gd‐DTPA, P = 0.28). High ICCs of 0.96 ( P < 0.01) were noted both at precontrast and postcontrast. Conclusion dGEMRIC using gadoteric acid is feasible and yields comparable values when compared with Gd‐DTPA. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1433–1440.