Premium
Early marker of regional left ventricular deformation in patients with hypertrophic cardiomyopathy evaluated by MRI tissue tracking: The effects of myocardial hypertrophy and fibrosis
Author(s) -
Xu Huayan,
Chen Jing,
Yang Zhigang,
Li Rui,
Shi Ke,
Zhang Qin,
Liu Xi,
Xie Linjun,
Jiang Li,
Guo Yingkun
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25681
Subject(s) - hypertrophic cardiomyopathy , radial stress , medicine , myocardial fibrosis , cardiology , magnetic resonance imaging , strain (injury) , fibrosis , muscle hypertrophy , left ventricular hypertrophy , cardiomyopathy , cardiac magnetic resonance , heart failure , radiology , deformation (meteorology) , physics , meteorology , blood pressure
Purpose To evaluate the regional left ventricular (LV) myocardial strain of early stage hypertrophic cardiomyopathy (HCM) patients by magnetic resonance (MR) tissue tracking. Materials and Methods In all, 114 adult HCM patients classified as NYHA I or II and 32 healthy volunteers were enrolled and underwent 3.0T MR examination. Vertical 2‐chamber long axis, horizontal 4‐chamber, and short axis cine sequence as well as late gadolinium enhancement images (LGE) were scanned. The cardiac function, regional LV tissue tracking variables, end‐diastolic wall thickness (EDTH), and LGE extent were measured. Results In the HCM group, 38 were NYHA I and 76 were NYHA II. By regional analysis, peak strain (PS) and peak displacement (PD) with radial, circumferential direction of hypertrophic segments ( n = 283) were significantly lower than nonhypertrophic segments ( n = 1541) (all P < 0.05). Radial PS was significantly correlated with LVEDTH ( r = −0.467, P < 0.0001). Radial PD was negatively associated with LVEDTH ( r = −0.331, P < 0.0001). The PS and PD of all directions were decreased in segments with LGE ( n = 723) compared with those without LGE ( n = 1101) (all P < 0.05). In addition, radial PS and PD were negatively associated with LGE extent (radial PS, r = −0.441; radial PD, r = −0.274; both P < 0.0001). All strain parameters showed excellent inter‐ and intraobserver agreements. Conclusion Decreased regional LV myocardial strain hypertrophic and fibrotic segments of early‐stage HCM patients can be measured by MR tissue tracking based on routine cine images. Moreover, myocardial strain may decrease with the increasing of myocardial hypertrophy as well as fibrosis. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1368–1376.