Premium
MR measurement of luminal water in prostate gland: Quantitative correlation between MRI and histology
Author(s) -
Sabouri Shirin,
Fazli Ladan,
Chang Silvia D.,
Savdie Richard,
Jones Edward C.,
Goldenberg S. Larry,
Black Peter C.,
Kozlowski Piotr
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25624
Subject(s) - spearman's rank correlation coefficient , rank correlation , correlation , histology , magnetic resonance imaging , prostate , nuclear medicine , prostatectomy , correlation coefficient , nuclear magnetic resonance , medicine , prostate cancer , anatomy , mathematics , physics , pathology , geometry , statistics , radiology , cancer
Purpose To determine the relationship between parameters measured from luminal water imaging (LWI), a new magnetic resonance imaging (MRI) T 2 mapping technique, and the corresponding tissue composition in prostate. Materials and Methods In all, 17 patients with prostate cancer were examined with a 3D multiecho spin echo sequence at 3T prior to undergoing radical prostatectomy. Maps of seven MR parameters, called N, T 2‐short , T 2‐long , A short , A long , geometric mean T 2 time (gm T 2 ), and luminal water fraction (LWF), were generated using nonnegative least squares (NNLS) analysis of the T 2 decay curves. MR parametric maps were correlated to digitized whole‐mount histology sections. Percentage area of tissue components, including luminal space, nuclei, and cytoplasm plus stroma, was measured on the histology sections by using color‐based image segmentation. Spearman's rank correlation test was used to evaluate the correlation between MR parameters and the corresponding tissue components, with particular attention paid to the correlation between LWF and percentage area of luminal space. Results N, T 2‐short , A long , gm T 2 , and LWF showed significant correlation ( P < 0.05) with percentage area of luminal space and stroma plus cytoplasm. T 2‐short and gm T 2 also showed significant correlation ( P < 0.05) with percentage area of nuclei. Overall, the strongest correlation was observed between LWF and luminal space (Spearman's coefficient of rank correlation = 0.75, P < 0.001). Conclusion Results of this study show that LWF measured with MRI is strongly correlated with the fractional amount of luminal space in prostatic tissue. This result suggests that LWI can potentially be applied for evaluation of prostatic diseases in which the extent of luminal space differs between normal and abnormal tissues. Level of Evidence: 1 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:861–869