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BOLD‐fMRI with median nerve electrical stimulation predict hemodynamic improvement after revascularization in patients with moyamoya disease
Author(s) -
Qiao PengGang,
Han Cong,
Qian Tianyi,
Li GongJie,
Yin Hong
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25598
Subject(s) - medicine , moyamoya disease , magnetic resonance imaging , asymptomatic , hemodynamics , stimulation , haemodynamic response , functional magnetic resonance imaging , blood oxygen level dependent , anesthesia , cardiology , nuclear medicine , radiology , blood pressure , heart rate
Purpose To assess the severity of cerebral hemodynamic impairment and hemodynamic improvements, after revascularization in moyamoya disease (MMD) by means of blood‐oxygen‐level dependent functional magnetic resonance imaging (BOLD‐fMRI). Materials and Methods BOLD‐fMRI with median nerve electrical stimulation based on echo planar imaging was performed in 73 volunteers with MMD and 15 healthy volunteers using a 3.0 Tesla MRI scanner. Twenty‐four MMD patients were reexamined after encephaloduroarteriosynangiosis. Time‐signal intensity curves of the activated area of the contralateral primary somatosensory cortex were computed. Negative response time (Tnr) and peak (Pnr), positive response time (Tpr) and peak (Ppr), and time to negative peak (TTPn) and positive peak (TTPp) were measured. Results Compared with nonparesthesia group and the asymptomatic side of paresthesia group, the patients with paresthesia showed extended Tnr (22.04 ± 3.34 s versus 9.57 ± 2.27 s and 12.67 ± 2.69 s, P = 0.0096), decreased Pnr (–0.47 ± 0.06 versus –0.30 ± 0.09 and –0.33 ± 0.09, P = 0.010), delayed TTPn (9.04 ± 1.39 s versus 3.66 ± 0.79 s and 4.88 ± 1.10 s, P = 0.0064), shortened Tpr (22.75 ± 2.30 s versus 36.85 ± 2.68 s and 33 ± 2.49 s, P = 0.0010), and decreased Ppr (0.62 ± 0.08 versus 0.99 ± 0.15 and 0.97 ± 0.11, P = 0.0149) when subjected to median nerve electrical stimulation in the symptomatic side. After surgery, the patients with paresthesia showed shorter Tnr (1.53 ± 1.66 s versus 17.88 ± 22.61 s, P = 0.0002), increased Pnr (–0.14 ± 0.17 versus –0.44 ± 0.53, P = 0.0178), advanced TTPn (1.29 ± 1.21 s versus 7.29 ± 8.21 s, P = 0.0005), extended Tpr (36.94 ± 6.41 s versus 25.18 ± 15.51 s, P = 0.0091), increased Ppr (1.21 ± 0.87 versus 0.77 ± 0.60, P = 0.0201), and advanced TTPp (11.18 ± 4.70 s versus 27.29 ± 20.00 s, P = 0.0046). Conclusion Bold‐fMRI is useful to assess disease severity and surgical efficacy in MMD. Level of Evidence: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2017;46:1159–1166.