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Noninvasive hepatic fibrosis staging using mr elastography: The usefulness of the bayesian prediction method
Author(s) -
Ichikawa Shintaro,
Motosugi Utaroh,
Enomoto Nobuyuki,
Matsuda Masanori,
Onishi Hiroshi
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25551
Subject(s) - cutoff , medicine , magnetic resonance elastography , bayesian probability , magnetic resonance imaging , fibrosis , stage (stratigraphy) , radiology , elastography , nuclear medicine , ultrasound , mathematics , statistics , physics , paleontology , quantum mechanics , biology
Purpose To evaluate the usefulness of the Bayesian method for hepatic fibrosis staging with magnetic resonance elastography (MRE). Materials and Methods The sample of this retrospective study comprised patients with chronic liver disease ( n = 309), in whom histopathological fibrosis staging and MRE using either a 1.5T ( n = 214) or a 3T magnetic resonance imaging (MRI) system ( n = 95) had been performed. The optimal cutoff stiffness value was determined and used to calculate the discrimination ability of fibrosis staging by the cutoff method. The Bayesian method calculated post‐MRE probability of each fibrosis stage, yielding MRE‐based fibrosis staging without a cutoff value as well as the confidence of staging. We compared the discrimination ability in all patients and in a subgroup of patients with high (≥90%) posterior probability. Results The discrimination ability for hepatic fibrosis staging was comparable between the Bayesian method and the cutoff method in all patients because the accuracy of staging with the Bayesian method and the cutoff method in all patients was not different ( P = 1.0000). However, in patients with high posterior probability by the Bayesian method, the accuracy of staging with the Bayesian method was significantly improved compared with that of the cutoff method in all patients; for discriminating stage ≥F2 from F0–F1 (98.9% vs. 94.8%, P = 0.0069); for ≥F3 (99.6% vs. 92.6%, P < 0.0001); and for F4 (100% vs. 94.2%, P = 0.0002). Conclusion The Bayesian method has a highly accurate discrimination ability for noninvasive hepatic fibrosis staging using MRE, if the posterior probability is high. Level of Evidence : 3 Technical Efficacy : Stage 2 J. MAGN. RESON. IMAGING 2017;46:375–382