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One‐month apparent diffusion coefficient correlates with response to radiofrequency ablation of hepatocellular carcinoma
Author(s) -
Barat Maxime,
Fohlen Audrey,
Cassinotto Christophe,
Jannot Anne Sophie,
Dautry Raphael,
Pelage JeanPierre,
Boudiaf Mourad,
Pocard Marc,
Eveno Clarisse,
Taouli Bachir,
Soyer Philippe,
Dohan Anthony
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25521
Subject(s) - medicine , hepatocellular carcinoma , effective diffusion coefficient , receiver operating characteristic , radiofrequency ablation , magnetic resonance imaging , diffusion mri , radiology , stage (stratigraphy) , complete response , multivariate analysis , ablation , nuclear medicine , chemotherapy , paleontology , biology
Purpose To assess whether apparent diffusion coefficient (ADC) values at 1 and 3 months after radiofrequency ablation (RFA) may be associated with a favorable response to therapy for hepatocellular carcinoma (HCC) and liver metastases. Materials and Methods Fifty‐nine patients with HCC ( n = 35) or liver metastases ( n = 24) who underwent 1.5T diffusion‐weighted magnetic resonance imaging (DWMRI) at 1 and 3 months post‐RFA were included. ADC values of patients with local tumor recurrence were compared to those without local recurrence. A subgroup analysis was performed for HCC and metastases. Results Thirty‐eight HCC and 27 metastases were evaluated. The ADC value of HCC at 1 month after RFA was lower in recurrent tumors (0.957 ± 0.229 [SD] × 10 −3 mm 2 ) compared to tumors with complete response (1.414 ± 0.322 [SD] × 10 −3 mm 2 /s, P = 0.006). At multivariate analysis, ADC at 1 month was the single independent variable associated with recurrence for HCC (area under the receiver operating characteristic curve = 0.860). No significant association was observed for liver metastases ( P = 0.089). Conclusion A low ADC value at 1 month after RFA is associated with an early local recurrence of HCC. This study does not confirm that such association exists for hepatic metastases. Level of Evidence : 3 Technical Efficacy : Stage 2 J. MAGN. RESON. IMAGING 2017;45:1648–1658