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Longitudinal study using voxel‐based relaxometry: Association between cartilage T 1ρ and T 2 and patient reported outcome changes in hip osteoarthritis
Author(s) -
Pedoia Valentina,
Gallo Matthew C.,
Souza Richard B.,
Majumdar Sharmila
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25458
Subject(s) - cartilage , osteoarthritis , medicine , relaxometry , voxel , nuclear medicine , magnetic resonance imaging , radiology , pathology , anatomy , alternative medicine , spin echo
Purpose To study the local distribution of hip cartilage T 1ρ and T 2 relaxation times and their association with changes in patient reported outcome measures (PROMs) using a fully automatic, local, and unbiased method in subjects with and without hip osteoarthritis (OA). Materials and Methods The 3 Tesla MRI studies of the hip were obtained for 37 healthy controls and 16 subjects with radiographic hip OA. The imaging protocol included a three‐dimensional (3D) SPGR sequence and a combined 3D T 1ρ and T 2 sequence. Quantitative cartilage analysis was compared between a traditional region of interest (ROI)‐based method and a fully automatic voxel‐based relaxometry (VBR) method. Additionally, VBR was used to assess local T 1ρ and T 2 differences between subjects with and without OA, and to evaluate the association between T 1ρ and T 2 and 18‐month changes PROMs. Results Results for the two methods were consistent in the acetabular (R = 0.79; coefficients of variation [CV] = 2.9%) and femoral cartilage (R = 0.90; CV = 2.6%). VBR revealed local patterns of T 1ρ and T 2 elevation in OA subjects, particularly in the posterosuperior acetabular cartilage (T 1ρ : P = 0.02; T 2 : P = 0.038). Overall, higher T 1ρ and T 2 values at baseline, particularly in the anterosuperior acetabular cartilage (T 1ρ : Rho = ‐0.42; P = 0.002; T 2 : Rho = ‐0.44; P = 0.002), were associated with worsening PROMS at 18‐month follow‐up. Conclusion VBR is an accurate and robust method for quantitative MRI analysis in hip cartilage. VBR showed the capability to detect local variations in T 1ρ and T 2 values in subjects with and without osteoarthritis, and voxel based correlations demonstrated a regional dependence between baseline T 1ρ and T 2 values and changes in PROMs. Level of Evidence : 1 J. MAGN. RESON. IMAGING 2017;45:1523–1533