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Assessment of Nonalcoholic Fatty Liver Disease in Rats Using Quantitative Dynamic Contrast‐Enhanced MRI
Author(s) -
Wu Zhuo,
Cheng ZiLiang,
Yi ZhiLong,
Xie MingWei,
Zeng Hong,
Lu LieJing,
Xu Xiao,
Shen Jun
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25455
Subject(s) - nonalcoholic fatty liver disease , medicine , receiver operating characteristic , steatosis , magnetic resonance imaging , stage (stratigraphy) , fibrosis , nonalcoholic steatohepatitis , grading (engineering) , liver disease , fatty liver , dynamic contrast enhanced mri , gastroenterology , nuclear medicine , radiology , disease , paleontology , civil engineering , biology , engineering
Purpose To evaluate the usefulness of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in the assessment of nonalcoholic fatty liver disease (NAFLD) severity. Materials and Methods Liver DCE‐MRI at 3.0T was performed in 36 adult Sprague–Dawley rats with methionine choline‐deficient diet‐induced NAFLD and 10 untreated control rats. Pharmacokinetic parameters of DCE‐MRI including K trans , K ep , V e , V p , and hepatic portal index (HPoI) were measured using the dual‐input extended Tofts model. Animals were categorized as normal ( n = 10), simple steatosis (SS, n = 11), borderline nonalcoholic steatohepatitis (bNASH, n = 20), and NASH ( n = 5) subgroups according to the NAFLD activity score system, and classified into F0 ( n = 24), F1 ( n = 11), F2 ( n = 7), and F3 ( n = 4) subgroups according to an established scoring system. DCE‐MRI parameters were compared. Receiver operating characteristic analyses were performed to assess the diagnostic performance of various DCE‐MRI parameters in grading NAFLD activity and staging liver fibrosis. Results K trans and HPoI were elevated with increasing severity of NAFLD activity and increased fibrosis stage. The areas under the receiver operating characteristic curve (AUROCs) of HPoI ranged from 0.895–0.951 for discriminating between different grades of NAFLD activity, and the AUROC was 0.852 for discriminating F0 stage from overall F1–F3 stages. The AUROC of K trans for discriminating non‐NASH from bNASH and NASH groups was 0.968, and 0.898 for discriminating between normal and overall fibrosis groups. Conclusion DCE‐MRI may play a role in assessing NAFLD severity. Level of Evidence : 1 J. MAGN. RESON. IMAGING 2017;45:1485–1493