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Diffusion‐weighted MRI of pulmonary lesions: Comparison of apparent diffusion coefficient and lesion‐to‐spinal cord signal intensity ratio in lesion characterization
Author(s) -
Çakmak Vefa,
Ufuk Furkan,
Karabulut Nevzat
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25426
Subject(s) - medicine , effective diffusion coefficient , receiver operating characteristic , nuclear medicine , magnetic resonance imaging , diffusion mri , lesion , confidence interval , radiology , lung cancer , area under the curve , pathology
Purpose To evaluate the diagnostic performance of minimum apparent diffusion coefficient (ADC min ) and lesion‐to‐spinal cord signal intensity ratio (LSR) in the differentiation of benign and malignant pulmonary lesions. Materials and Methods Forty‐seven patients (36 men, 11 women; range, 17–81 years) with 62 pulmonary lesions underwent magnetic resonance imaging (MRI) and diffusion‐weighted imaging (DWI) performed using a 1.5T scanner during free‐breathing using b 600 s/mm 2 . The ADC min values and LSR were calculated. A receiver operating characteristic (ROC) curve analysis was performed to detect the threshold value of the ADC min and LSR values for discrimination between benign and malignant pulmonary lesions. Results There were 42 malignant (33 primary tumors, 9 metastases) and 20 benign lesions. The mean ADC min ± standard deviations (×10 −3 mm 2 /s) were 1.45 ± 0.33 for malignant tumors, and 2.4 ± 0.69 for benign lesions ( P < 0.001). The mean LSR ± standard deviations for lung cancer was 1.24 ± 0.78, and for benign lesions was 0.55 ± 0.57 ( P < 0.001). The area under the ROC curve for ADC min (0.931; 95% confidence interval [CI]: 0.868–0.993) was greater than that for LSR (0.801; 95% CI: 0.675–0.926) ( P = 0.029). For benign/malignant discrimination, the ROC curve showed threshold value of ADC min to be 1.78 × 10 −3 mm 2 /s and that of LSR to be 0.86. Using these cutoff values, accuracy of ADC min and LSR were 89%, 74%, respectively ( P = 0.383). Conclusion Being a contrast‐free and radiation‐free technique, DWI allows discrimination of benign and malignant lung lesions. The ADC min value performed marginally better than LSR values in distinction of benign and malignant lesions. Level of Evidence: 1 J. Magn. Reson. Imaging 2017;45:845–854.