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Detection of the mild emphysema by quantification of lung respiratory airways with hyperpolarized xenon diffusion MRI
Author(s) -
Ruan Weiwei,
Zhong Jianping,
Wang Ke,
Wu Guangyao,
Han Yeqing,
Sun Xianping,
Ye Chaohui,
Zhou Xin
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25408
Subject(s) - xenon , effective diffusion coefficient , lung , magnetic resonance imaging , respiratory system , nuclear medicine , medicine , in vivo , diffusion mri , lung volumes , diffusion , nuclear magnetic resonance , pathology , chemistry , radiology , physics , microbiology and biotechnology , organic chemistry , biology , thermodynamics
Purpose To demonstrate the feasibility to quantify the lung respiratory airway in vivo with hyperpolarized xenon diffusion magnetic resonance imaging (MRI), which is able to detect mild emphysema in the rat model. Materials and Methods The lung respiratory airways were quantified in vivo using hyperpolarized xenon diffusion MRI (7T) with eight b values (5, 10, 15, 20, 25, 30, 35, 40 s/cm 2 ) in five control rats and five mild emphysematous rats, which were induced by elastase. The morphological results from histology were acquired and used for comparison. Results The parameters D L (longitudinal diffusion coefficient), r (internal radius), h (alveolar sleeve depth), Lm (mean linear intercept), and S/V (surface area to lung volume ratio) derived from the hyperpolarized xenon diffusion MRI in the emphysematous group showed significant differences from those in the control group ( P < 0.05). Additionally, these parameters correlated well with the Lm obtained by the traditional histological sections (Pearson's correlation coefficients >0.8). Conclusion The lung respiratory airways can be quantified by hyperpolarized xenon diffusion MRI, showing the potential for mild emphysema diagnosis. Also, the study suggested that the hyperpolarized xenon D L is more sensitive than D T (transverse diffusion coefficient) to detect mild emphysema. Level of Evidence: 1 J. Magn. Reson. Imaging 2017;45:879–888.