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Intravoxel incoherent motion imaging measurement of perfusion changes in the parotid gland provoked by gustatory stimulation: A pilot study
Author(s) -
Becker Anton S.,
Manoliu Andrei,
Wurnig Moritz C.,
Boss Andreas
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25393
Subject(s) - intravoxel incoherent motion , nuclear medicine , perfusion , medicine , magnetic resonance imaging , stimulation , diffusion mri , dynamic contrast enhanced mri , radiology
Purpose To demonstrate the feasibility of intravoxel incoherent motion imaging (IVIM) for quantification of perfusion changes in the parotid gland after gustatory stimulation. Materials and Methods Eight healthy volunteers underwent diffusion‐weighted magnetic resonance imaging (MRI) of the neck at 3T with 11 dynamic acquisitions (9 b‐values between 0 and 980 s/mm 2 , 2:40 min each). After 5:20 minutes, a lemon‐mint‐drop was administered orally. Perfusion fraction (F p ), pseudodiffusion (D*), tissue diffusion (D t ) coefficients, and optimal b‐value threshold were measured using a multistep variable b‐value threshold fitting approach. Dynamic changes in the coefficients between three exemplary timepoints (baseline, after stimulation, after dissolution) were compared using a Mann–Whitney U ‐test with Bonferroni correction ( P < 0.016 significance level). Results Mean values (95% confidence interval [CI]) for IVIM parameters at baseline were F p : 0.11 (0.08–0.15), D*: 56.48 mm 2 /s (39.71–98.27), D t : 1.01 mm 2 /s (0.84–1.06), b‐value threshold: 30 s/mm 2 (21.25–105). After stimulation: F p 0.16 (0.15–0.24; P < 0.01), D* 93.83 mm 2 /s (77.98–129.53, P = 0.25), D t 0.93 mm 2 /s (0.87–1.08, P = 0.94), b‐value threshold 20 s/mm 2 (13.75–26.25 s/mm 2 , P = 0.10), reflecting the increase in tissue perfusion. After dissolution of the drop: F p : 0.13 (0.11–0.18, P = 0.38), D*: 101.61 mm 2 /s (90.68–144.55, P = 0.07), D t : 0.91 mm 2 /s (0.85–1.05, P = 0.64), b‐value threshold: 15 s/mm 2 (11.25–40, P = 0.38). Conclusion The IVIM method allows for simultaneous quantification of changes in perfusion and diffusion effects after gustatory stimulation of the parotid gland. Level of Evidence: 2 J. Magn. Reson. Imaging 2017;45:570–578.