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Dynamic contrast‐enhanced and diffusion‐weighted MRI of estrogen receptor‐positive invasive breast cancers: Associations between quantitative MR parameters and Ki‐67 proliferation status
Author(s) -
Shin Jong Ki,
Kim Jin You
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25348
Subject(s) - dynamic contrast , estrogen receptor , breast cancer , diffusion mri , medicine , estrogen , dynamic contrast enhanced mri , oncology , pathology , magnetic resonance imaging , radiology , cancer
Purpose To explore the association between quantitative parameters derived from dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and diffusion‐weighted imaging (DWI) and Ki‐67 proliferation status in patients with estrogen receptor (ER)‐positive invasive breast cancer. Materials and Methods We retrospectively reviewed the records of 88 patients with ER‐positive invasive breast cancer who underwent preoperative DCE‐MRI and DWI on a 3T scanner. Perfusion parameters (K trans , K ep , and V e ) and apparent diffusion coefficients (ADCs) were recorded, and we correlated these data with the Ki‐67 status. The Ki‐67 proliferation index was categorized as high (≥14%) or low (<14%). Results In the high‐Ki‐67 group, the mean K trans was significantly higher ( P < 0.001) than that of the low‐Ki‐67 group, and the mean ADC significantly lower ( P < 0.001). However, the mean K ep and V e values did not differ between the two groups ( P = 0.248 and P = 0.055, respectively). Univariate analysis showed that a higher K trans (>0.274), a lower ADC (≤0.893 × 10 −3 mm 2 /s), a larger tumor size (>2 cm), a higher histological grade (grade 3), the presence of axillary metastasis, and positive P53 status were significantly associated with high‐Ki‐67 status (all P values < 0.05). Of these variables, a higher K trans (>0.274; adjusted odds ratio [OR] = 9.027, 95% confidence interval [CI] = 1.929–42.245; P = 0.005) and a higher histological grade (grade 3; adjusted OR = 7.510, 95% CI = 1.305–43.205; P = 0.024) independently predicted a high Ki‐67 status. Conclusion K trans derived from DCE‐MRI is associated independently with the Ki‐67 proliferation status in patients with ER‐positive invasive breast cancer. Level of Evidence: 4 J. Magn. Reson. Imaging 2017;45:94–102.