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Haralick textural features on T 2 ‐weighted MRI are associated with biochemical recurrence following radiotherapy for peripheral zone prostate cancer
Author(s) -
Gnep Khémara,
Fargeas Auréline,
GutiérrezCarvajal Ricardo E.,
Commandeur Frédéric,
Mathieu Romain,
Ospina Juan D.,
Rolland Yan,
Rohou Tanguy,
Vincendeau Sébastien,
Hatt Mathieu,
Acosta Oscar,
de Crevoisier Renaud
Publication year - 2017
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25335
Subject(s) - prostate cancer , magnetic resonance imaging , medicine , radiation therapy , prostate , effective diffusion coefficient , nuclear medicine , biochemical recurrence , cancer , radiology , prostatectomy
Purpose To explore the association between magnetic resonance imaging (MRI), including Haralick textural features, and biochemical recurrence following prostate cancer radiotherapy. Materials and Methods In all, 74 patients with peripheral zone localized prostate adenocarcinoma underwent pretreatment 3.0T MRI before external beam radiotherapy. Median follow‐up of 47 months revealed 11 patients with biochemical recurrence. Prostate tumors were segmented on T 2 ‐weighted sequences ( T 2 ‐w) and contours were propagated onto the coregistered apparent diffusion coefficient (ADC) images. We extracted 140 image features from normalized T 2 ‐w and ADC images corresponding to first‐order ( n = 6), gradient‐based ( n = 4), and second‐order Haralick textural features ( n = 130). Four geometrical features (tumor diameter, perimeter, area, and volume) were also computed. Correlations between Gleason score and MRI features were assessed. Cox regression analysis and random survival forests (RSF) were performed to assess the association between MRI features and biochemical recurrence. Results Three T 2 ‐w and one ADC Haralick textural features were significantly correlated with Gleason score ( P < 0.05). Twenty‐eight T 2 ‐w Haralick features and all four geometrical features were significantly associated with biochemical recurrence ( P < 0.05). The most relevant features were Haralick features T 2 ‐w contrast, T 2 ‐w difference variance, ADC median, along with tumor volume and tumor area (C‐index from 0.76 to 0.82; P < 0.05). By combining these most powerful features in an RSF model, the obtained C‐index was 0.90. Conclusion T 2 ‐w Haralick features appear to be strongly associated with biochemical recurrence following prostate cancer radiotherapy. Level of Evidence: 3 J. Magn. Reson. Imaging 2017;45:103–117.