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Efficient method for volumetric assessment of peak blood flow velocity using 4D flow MRI
Author(s) -
Rose Michael J.,
Jarvis Kelly,
Chowdhary Varun,
Barker Alex J.,
Allen Bradley D.,
Robinson Joshua D.,
Markl Michael,
Rigsby Cynthia K.,
Schnell Susanne
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25305
Subject(s) - magnetic resonance imaging , medicine , intraclass correlation , descending aorta , reproducibility , blood flow , aorta , nuclear medicine , bicuspid aortic valve , ascending aorta , doppler effect , radiology , nuclear magnetic resonance , cardiology , mathematics , physics , clinical psychology , statistics , astronomy , psychometrics
Purpose To test the feasibility and effectiveness of using maximum intensity plots (MIPs) based on 4D flow magnetic resonance imaging (MRI) velocity data to assess systolic peak velocities in a cohort of bicuspid aortic valve (BAV) patients. Materials and Methods 4D flow MRI at 1.5T was performed on 51 BAV patients. MIPs were generated from the 4D flow MRI velocity data and used by two users to determine peak velocities in three regions of interest (ROIs): ascending aorta (AAo), aortic arch, and descending aorta. 4D flow MRI peak velocities in the AAo were compared to peak velocities recorded by 2D phase contrast MRI (2D PCMRI) in a subcohort of 36 patients and by Doppler echocardiography in a subcohort of 34 patients. 4D flow MRI peak velocities recorded by each observer were compared for all ROIs to test for interobserver variability. Results 4D flow MRI recorded significantly higher velocities compared to 2D PCMRI (2.04 ± 0.71 m/s vs. 1.69 ± 0.79 m/s, 17.2% difference, P < 0.001) and similar velocities compared to Doppler echocardiography. There was excellent agreement between the observers, with a mean difference of 0.005 m/s and an intraclass correlation coefficient of 0.98. Conclusion 4D flow MRI velocity MIPs allow for efficient measurement of peak velocities in BAV patients with higher accuracy than 2D PCMRI and similar accuracy to Doppler echocardiography. J. Magn. Reson. Imaging 2016;44:1673–1682.