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Value of higher‐resolution MRI in assessing middle cerebral atherosclerosis and predicting capsular warning syndrome
Author(s) -
Xu Xin,
Wei Yafen,
Zhang Xiandong,
Yang Lili,
Cui Zhitang,
Yan Junjie
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25265
Subject(s) - medicine , middle cerebral artery , magnetic resonance imaging , confidence interval , stroke (engine) , odds ratio , cerebral infarction , infarction , radiology , cardiology , nuclear medicine , myocardial infarction , ischemia , mechanical engineering , engineering
Purpose To investigate the correlation between middle cerebral atherosclerosis and capsular warning syndrome (CWS) and assess the value of higher‐resolution magnetic resonance imaging (MRI) in prognostication. Materials and Methods In all, 97 transient ischemic attack (TIA) patients who underwent an MRI from February 2010 to December 2013 were included in the retrospective study and divided into either a CWS or middle cerebral artery (MCA) TIA group according to their eventual clinical diagnosis. 3T MRI included fast‐spin echo T 2 ‐weighted imaging, double‐inverse recovery T 1 ‐weighted imaging, and T 1 contrast‐enhanced scan sequences. Baseline characteristics, MRI results in terms of MCA plaque formation, plaque characteristics such as enhancement, and development of infarction were compared between the two groups to study the distribution and characteristics of cerebral atherosclerotic plaques. Multivariate analysis identified factors associated with infarction 1 week after plaque identification. Results Based on the MR images, 76% of both groups of patients had middle cerebral atherosclerosis. Compared to TIA patients, the median age of CWS patients was younger (58 [range 42–73] vs. 67 [36–84] years, P = 0.003), and CWS patients had a lower rate of stroke history (10.9% vs. 41.2%, P = 0.001). Infarction was more common in CWS patients than in TIA patients (52.2% vs. 20.5%, P = 0.003) and a superior plaque was correlated with infarction occurrence (odds ratio 5.674, 95% confidence interval 1.112–28.958). Conclusion Patients with CWS have large arterial plaques, including MCA plaques. There was a correlation between CWS and the MCA plaque location. J. Magn. Reson. Imaging 2016;44:1277–1283.