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Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme
Author(s) -
Yamashita Koji,
Hiwatashi Akio,
Togao Osamu,
Kikuchi Kazufumi,
Kitamura Yoshiyuki,
Mizoguchi Masahiro,
Yoshimoto Koji,
Kuga Daisuke,
Suzuki Satoshi O.,
Baba Shingo,
Isoda Takuro,
Iwaki Toru,
Iihara Koji,
Honda Hiroshi
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25261
Subject(s) - intravoxel incoherent motion , nuclear medicine , medicine , primary central nervous system lymphoma , glioblastoma , receiver operating characteristic , mann–whitney u test , standardized uptake value , positron emission tomography , effective diffusion coefficient , area under the curve , magnetic resonance imaging , radiology , lymphoma , pathology , cancer research
Purpose To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) MR imaging and 18 F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM). Materials and Methods Fifty patients, 17 with PCNSL and 33 with GBM, were retrospectively studied. From the 3 Tesla IVIM data, the perfusion fraction (f) and diffusion coefficient (D) were obtained. In addition, the maximum standard uptake value (SUV max ) was obtained from the FDG‐PET data. Each of the three parameters was compared between PCNSL and GBM using Mann‐Whitney U‐test. The performance in discriminating between PCNSL and GBM was evaluated using receiver‐operating characteristics analysis and area‐under‐the‐curve (AUC) values for the three parameters. Results The f max and D min values were significantly higher in GBM than in PCNSL ( P < 0.01 and P < 0.0001, respectively). In addition, the SUV max value was significantly lower in GBM than in PCNSL ( P < 0.0005). The AUC values for f max , D min , and SUV max were 0.756, 0.905, and 0.857, respectively. The combination of the f max and D min increased the diagnostic performance (AUC = 0.936) of f max ( P < 0.05), but this value was not significantly different from the values for D min ( P = 0.30). Conclusion IVIM‐MR imaging noninvasively provides useful quantitative information in distinguishing between PCNSL and GBM. J. Magn. Reson. Imaging 2016;44:1256–1261.