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Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T
Author(s) -
Wu Yuankui,
Agarwal Shruti,
Jones Craig K.,
Webb Andrew G.,
van Zijl Peter C.M.,
Hua Jun,
Pillai Jay J.
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25248
Subject(s) - medicine , nuclear medicine , cerebral blood volume , perfusion , magnetic resonance imaging , blood volume , correlation , radiology , contrast (vision) , geometry , mathematics , artificial intelligence , computer science
Purpose Arteriolar cerebral‐blood‐volume (CBVa) is an important perfusion parameter that can be measured using inflow‐based vascular‐space‐occupancy (iVASO) MRI without exogenous contrast agent administration. The purpose of this study is to assess the potential diagnostic value of CBVa in brain tumor patients by comparing it with total‐CBV (including arterial, capillary and venous vessels) measured by dynamic‐susceptibility‐contrast (DSC) MRI. Materials and Methods Twelve brain tumor patients were scanned using iVASO (on 7T as part of a research project) and DSC (on 3T as part of routine clinical protocols) MRI. Region‐of‐interest analysis was performed to compare the resulting perfusion measures between tumoral and contralateral regions, and to evaluate their associations with tumor grades. Results CBVa measured by iVASO MRI significantly correlated with WHO grade (ρ = 0.37, P = 0.04). Total‐CBV measured by DSC MRI showed a trend of correlation with WHO grade (ρ = 0.28, P = 0.5). The signal‐to‐noise ratio was comparable ( P > 0.1) between the two methods, while the contrast‐to‐noise ratio between tumoral and contralateral regions was higher in iVASO‐CBVa than DSC‐CBV in WHO II/III patients ( P < 0.05) but comparable in WHO IV patients ( P > 0.1). A trend of positive correlation between DSC‐CBV and iVASO‐CBVa was observed (R 2 = 0.28, P = 0.07). Conclusion In this initial patient study, CBVa demonstrated a stronger correlation with WHO grade than total‐CBV. Further investigation with a larger cohort is warranted to validate whether CBVa can be a better classifier than total‐CBV for the stratification of brain tumors, and whether iVASO MRI can be a useful alternative method for the assessment of tumor perfusion, especially when exogenous contrast agent administration is difficult in certain patient populations. J. Magn. Reson. Imaging 2016;44:1244–1255.