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MRI In rectal cancer: Correlations between MRI features and molecular markers Ki‐67, HIF‐1α, and VEGF
Author(s) -
Meng Xiangjiao,
Li Huijuan,
Kong Lingling,
Zhao Xianguang,
Huang Zhaoqin,
Zhao Hanxi,
Zhu Wanqi,
Li Xiaolin,
Yu Jinming,
Xing Ligang
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25195
Subject(s) - effective diffusion coefficient , magnetic resonance imaging , medicine , colorectal cancer , vascular endothelial growth factor , carcinoembryonic antigen , immunohistochemistry , ki 67 , nuclear medicine , diffusion mri , pathology , cancer , vegf receptors , radiology
Purpose To investigate whether the apparent diffusion coefficient (ADC) values acquired from diffusion‐weighted magnetic resonance imaging (DW‐MRI) are correlated with molecular markers Ki‐67, hypoxia‐inducible factor 1α (HIF‐1α), and vascular endothelial growth factor (VEGF) in rectal cancer (RC). Materials and Methods Ninety‐one patients (64 males and 27 females) diagnosed with rectal cancer underwent 3.0T DW‐MRI before any anticancer treatment. DW‐MRI was performed using the single‐shot echo‐planar imaging technique (b = 0 and b = 800 s/mm 2 ). The patients underwent surgery within 1 week after MRI. Ki‐67, HIF‐1α, and VEGF expression were assessed by immunohistochemistry at both the resected margins and the center of the tumor. Results We noted that ADC values correlated positively with histology differentiations ( r = 0.336, P = 0.001) and negatively with carcinoembryonic antigen level ( r = −0.217, P = 0.039) in RC. Both the value and the level of Ki‐67 expression were correlated inversely with the ADC values ( r = −0.475, P < 0.001 and r = −0.555, P < 0.001). There was a weak negative correlation between HIF‐1α expression and the ADC values ( r = −0.304, P = 0.003). VEGF expression was correlated inversely with the ADC values of the RCs ( r = −0.290, P = 0.005). However, no significant correlation was observed between VEGF expression and the ADC values in pT4 RCs ( r = −0.166, P = 0.255). Conclusion Our results suggest that the ADC values on DW‐MRI may be used as a measurement of cell proliferation and hypoxia in RC. J. Magn. Reson. Imaging 2016;44:594–600.