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Usefulness of MR elastography for detecting clinical progression of cirrhosis from child‐pugh class A to B in patients with type C viral hepatitis
Author(s) -
Takamura Tomohiro,
Motosugi Utaroh,
Ichikawa Shintaro,
Sano Katsuhiro,
Morisaka Hiroyuki,
Ichikawa Tomoaki,
Enomoto Nobuyuki,
Onishi Hiroshi
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25182
Subject(s) - cirrhosis , medicine , hepatocellular carcinoma , gastroenterology , hazard ratio , hepatitis c , viral hepatitis , hepatitis b , proportional hazards model , confidence interval
Purpose To evaluate the usefulness of magnetic resonance elastography (MRE) in detecting the clinical progression of cirrhosis from Child‐Pugh class A to B in patients with hepatitis C. Materials and Methods We reviewed the data of 101 consecutive patients with type C viral hepatitis and clinically suspected cirrhosis who fulfilled the all following criteria: available MRE at 1.5 Tesla (T) or 3.0T and laboratory tests within a month, Child‐Pugh class A, platelet count less than 155 × 10 3 /μL, no clinical history of hepatocellular carcinoma, and ≥6 months of follow‐up after MRE. We longitudinally analyzed the incidence of cirrhosis progression as defined by the clinical progression from Child‐Pugh class A to B at two subsequent follow‐up points. Risk of cirrhosis progression was assessed by Cox analyses and Kaplan‐Meyer methods. Results Cirrhosis progression was noted in 25 patients during the follow‐up period. Liver stiffness (hazard ratio [HR] by 1 kPa increase = 1.397; P = 0.0074), Child‐Pugh score of 6 versus score 5 (HR of 3.085; P = 0.0276), and treatment responses to anti‐viral therapy versus nonresponse (HR of <0.001, P = 0.0006) were independent risk factors of cirrhosis progression. The 1‐year risk (0.7%; 95% confidence interval, 0.1–4.2%) of cirrhosis progression was negligible in patients with liver stiffness of <3.3 kPa or response to anti‐viral treatment. Conclusion MRE is useful to stratify the risk of cirrhosis progression in patients with hepatitis C. J. Magn. Reson. Imaging 2016;44:715–722.