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Rapid T 2 mapping of mouse heart using the carr–purcell–meiboom–gill sequence and compressed sensing reconstruction
Author(s) -
Chen Yong,
Li Wen,
Jiang Kai,
Wang Charlie Y.,
Yu Xin
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25175
Subject(s) - imaging phantom , scanner , compressed sensing , magnetic resonance imaging , temporal resolution , nuclear magnetic resonance , image resolution , in vivo , resolution (logic) , materials science , physics , biomedical engineering , algorithm , computer science , optics , artificial intelligence , medicine , radiology , biology , microbiology and biotechnology
Purpose To develop and prove preliminary validation of a fast in vivo T 2 mapping technique for mouse heart. Materials and Methods Magnetic resonance imaging (MRI) experiments were performed on a 7T animal scanner. The standard Carr–Purcell–Meiboom–Gill (CPMG) sequence was modified to minimize the effect of stimulated echoes for accurate T 2 quantification. The acquisition was further accelerated with the compressed sensing approach. The accuracy of the proposed method was first validated with both phantom experiments and numerical simulations. In vivo T 2 measurement was performed on seven mice in a manganese‐enhanced MRI study. Results In phantom studies, T 2 values obtained with the modified CPMG sequence are in good agreement with the standard spin‐echo method ( P > 0.05). Numerical simulations further demonstrated that with the application of the compressed sensing approach, fast T 2 quantification with a spatial resolution of 2.3 mm can be achieved at a high temporal resolution of 1 minute per slice. With the proposed technique, an average T 2 value of 25 msec was observed for mouse heart at 7T and this number decreased significantly after manganese infusion ( P < 0.001). Conclusion A rapid T 2 mapping technique was developed and assessed, which allows accurate T 2 quantification of mouse heart at a temporal resolution of 1 minute per slice. J. Magn. Reson. Imaging 2016;44:375–382.