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USPIO‐enhanced 3D‐cine self‐gated cardiac MRI based on a stack‐of‐stars golden angle short echo time sequence: Application on mice with acute myocardial infarction
Author(s) -
Trotier Aurélien J.,
Castets Charles R.,
Lefrançois William,
Ribot Emeline J.,
Franconi JeanMichel,
Thiaudière Eric,
Miraux Sylvain
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25150
Subject(s) - myocardial infarction , medicine , nuclear medicine , ejection fraction , cardiac magnetic resonance imaging , magnetic resonance imaging , cardiology , radiology , heart failure
Purpose To develop and assess a 3D‐cine self‐gated method for cardiac imaging of murine models. Materials and Methods A 3D stack‐of‐stars (SOS) short echo time (STE) sequence with a navigator echo was performed at 7T on healthy mice ( n = 4) and mice with acute myocardial infarction (MI) ( n = 4) injected with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. In all, 402 spokes were acquired per stack with the incremental or the golden angle method using an angle increment of (360/402)° or 222.48°, respectively. A cylindrical k ‐space was filled and repeated with a maximum number of repetitions (NR) of 10. 3D cine cardiac images at 156 μm resolution were reconstructed retrospectively and compared for the two methods in terms of contrast‐to‐noise ratio (CNR). The golden angle images were also reconstructed with NR = 10, 6, and 3, to assess cardiac functional parameters (ejection fraction, EF) on both animal models. Results The combination of 3D SOS‐STE and USPIO injection allowed us to optimize the identification of cardiac peaks on navigator signal and generate high CNR between blood and myocardium (15.3 ± 1.0). The golden angle method resulted in a more homogeneous distribution of the spokes inside a stack ( P < 0.05), enabling reducing the acquisition time to 15 minutes. EF was significantly different between healthy and MI mice ( P < 0.05). Conclusion The method proposed here showed that 3D‐cine images could be obtained without electrocardiogram or respiratory gating in mice. It allows precise measurement of cardiac functional parameters even on MI mice. J. Magn. Reson. Imaging 2016;44:355–365.