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Signal decay mapping of myocardial edema using dual‐contrast fast spin‐echo MRI
Author(s) -
Krumm Patrick,
Martirosian Petros,
Rath Dominik,
Zitzelsberger Tanja,
Ruff Christer Andreas,
Klumpp Bernhard Daniel,
Nikolaou Konstantin,
Gawaz Meinrad,
Geisler Tobias,
Schick Fritz,
Kramer Ulrich
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25142
Subject(s) - edema , medicine , penumbra , magnetic resonance imaging , nuclear medicine , contrast (vision) , myocardial infarction , nuclear magnetic resonance , radiology , cardiology , ischemia , physics , optics
Purpose To introduce a dual‐contrast fast spin‐echo (dcFSE) sequence for signal decay mapping of myocardial edema. Materials and Methods After consultation with the Institutional Review Board, 22 acute myocardial infarction (MI) patients were examined with magnetic resonance imaging (MRI) at 1.5T 2 days after revascularization. Edema was evaluated in 16 myocardial segments with an exponential fit for signal decay time (SDT) in dcFSE mapping and T 2 signal intensity ratio for single‐contrast FSE. Myocardial viability was evaluated in late gadolinium enhancement (LGE). A control group of 10 volunteers was examined for edema imaging. SDT was compared in segment groups: 1) with LGE in MI, 2) penumbra, 3) remote from LGE, 4) controls. Groups 1/3 and 3/4 were tested on difference. Three phantoms providing similar T 2 but different T 1 relaxation times (low, intermediate, high) were examined with dcFSE and multicontrast spin echo sequence as a reference. Results The SDT/ T 2 ratio for segment groups was 1) 82msec/1.7 in segments with LGE; 2) 65msec/1.6 for penumbra, 3) 62msec/1.7 for remote segments, and 4) 50msec/1.6 in controls. In dcFSE group 1/3 ( P < 0.0001) and in group 3/4 ( P = 0.0002) SDT was significantly different. In single‐contrast FSE the T 2 ratio was not significantly different for both tests: 1/3 P = 0.1889; 3/4 P = 0.8879. T 2 ‐overestimation of dcFSE was 23% in low, 29% in intermediate, and 35% in highly T 1 contaminated phantoms. Conclusion dcFSE signal decay edema mapping is feasible in volunteers and patients. DcFSE SDT is superior to T 2 ratio for detection of high‐grade and diffuse myocardial edema. J. Magn. Reson. Imaging 2016;44:186–193.