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Correlation of standard diffusion‐weighted imaging and diffusion kurtosis imaging with distant metastases of rectal carcinoma
Author(s) -
Yu Jing,
Huang DongYa,
Li Yan,
Dai Xin,
Shi HaiBin
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25137
Subject(s) - medicine , kurtosis , effective diffusion coefficient , metastasis , magnetic resonance imaging , receiver operating characteristic , nuclear medicine , diffusion mri , radiology , rectal carcinoma , distant metastasis , area under the curve , colorectal cancer , pathology , cancer , mathematics , statistics
Purpose To investigate the correlation of standard diffusion‐weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with distant metastases of rectal carcinoma. Materials and Methods Fifty‐eight patients with rectal carcinoma (27 with distant metastasis and 31 with no metastasis) were included in this study. The apparent diffusion coefficient (ADC) value from standard DWI ( b values of 0 and 1000 sec/mm 2 ), D app , and K app from DKI ( b values of 0, 700, 1400, and 2000 sec/mm 2 ) were acquired with a 3.0T magnetic resonance imaging (MRI) scanner. These quantitative parameters were calculated from the entire tumors. Receiver operating characteristic curve analyses were conducted to assess the utility for discrimination of tumor with distant metastasis and those without metastasis. Parameters were compared using the independent‐samples t ‐test. Results The histogram metrics 10th percentile of D app ( D app‐10th ) and ADC values (ADC 10th ) were significantly lower in the distant metastasis group than those without metastasis (972.5 ± 118.8 vs. 1121.3 ± 133.8 × 10 −6 mm 2 /s, P = 0.03; 809.2 ± 67.1 vs. 856.2 ± 72.1 × 10 −6 mm 2 /s, P = 0.03). D app‐10th showed relatively higher area under the curve (AUC) (0.856 vs. 0.669, P = 0.024), and higher specificity (100% vs. 68%) than ADC 10th did for differentiation of lesions with distant metastasis from those without metastasis. Conclusion DKI was relatively better than standard DWI in discriminating rectal carcinoma with distant metastasis from those without metastasis. J. Magn. Reson. Imaging 2016;44:221–229.