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Evaluation of upper airway collapsibility using real‐time MRI
Author(s) -
Wu Ziyue,
Chen Weiyi,
Khoo Michael C.K.,
Davidson Ward Sally L.,
Nayak Krishna S.
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25133
Subject(s) - airway , medicine , obstructive sleep apnea , anesthesia , sleep apnea , continuous positive airway pressure , apnea , nuclear medicine , cardiology
Purpose To develop and demonstrate a real‐time MRI method for assessing upper airway collapsibility in sleep apnea. Materials and Methods Data were acquired on a clinical 3 Tesla scanner using a radial CAIPIRIHNA sequence with modified golden angle view ordering and reconstructed using parallel imaging and compressed sensing with temporal finite difference sparsity constraint. Segmented airway areas together with synchronized facemask pressure were used to calculate airway compliance and projected closing pressure, P close , at four axial locations along the upper airway. This technique was demonstrated in five adolescent obstructive sleep apnea (OSA) patients, three adult OSA patients and four healthy volunteers. Heart rate, oxygen saturation, facemask pressure, and abdominal/chest movements were monitored in real‐time during the experiments to determine sleep/wakefulness. Results Student's t‐tests showed that both compliance and P close were significantly different between healthy controls and OSA patients ( P < 0.001). The results also suggested that a narrower airway site does not always correspond to higher collapsibility. Conclusion With the proposed methods, both compliance and P close can be calculated and used to quantify airway collapsibility in OSA with an awake scan of 30 min total scan room time. J. Magn. Reson. Imaging 2016;44:158–167.