Premium
Alterations of neocortico‐limbic association fibers and correlation with diet in prediabetes diagnosed by impaired fasting glucose
Author(s) -
Hou YiCheng,
Yang ShwuHuey,
Wu YuTe,
Lai ChienHan
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25127
Subject(s) - prediabetes , association (psychology) , medicine , impaired fasting glucose , correlation , endocrinology , limbic system , physiology , diabetes mellitus , psychology , impaired glucose tolerance , type 2 diabetes , central nervous system , geometry , mathematics , psychotherapist
Purpose To assess the existence of alterations in the micro‐integrity of the fasciculus in prediabetic subjects. The issue of micro‐integrity in white matter tracts has not been adequately addressed in prediabetes. Materials and Methods Sixty‐four prediabetic subjects and 54 controls were enrolled. All participants completed 24‐hour diet records and 3‐day diet records and received diffusion tensor imaging at 3T. The data for white matter micro‐integrity were analyzed and compared between prediabetic subjects and controls with age and gender as covariates. In addition, voxel‐wise regression between white matter micro‐integrity, diet, and preprandial glucose levels were used to explore the relationship between white matter micro‐integrity and diet or serum glucose levels. Results We found that prediabetic subjects had significant reductions in the micro‐integrity of bilateral anterior thalamic radiation, left inferior longitudinal fasciculus, and left superior longitudinal fasciculus (corrected P < 0.05). In addition, total carbohydrate intake amount and preprandial serum glucose levels were negatively correlated with the micro‐integrity in the left inferior longitudinal fasciculus and left anterior thalamic radiation ( r : –0.47, corrected P < 0.05). Conclusion Restrictive alterations in the white matter micro‐integrity of the anterior thalamic radiation and inferior and superior longitudinal fasciculi might represent the initial “hot spots” for white matter tract alterations, which might play a role in the development of prediabetes. J. Magn. Reson. Imaging 2016;43:1500–1506.