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Gray and white matter alterations in early HIV‐infected patients: Combined voxel‐based morphometry and tract‐based spatial statistics
Author(s) -
Wang Bo,
Liu Zhenyu,
Liu Jiaojiao,
Tang Zhenchao,
Li Hongjun,
Tian Jie
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25100
Subject(s) - fractional anisotropy , white matter , diffusion mri , external capsule , corpus callosum , internal capsule , medicine , voxel , nuclear medicine , voxel based morphometry , pathology , magnetic resonance imaging , radiology
Purpose To investigate both the gray matter (GM) and whiter matter (WM) alterations in a homogeneous cohort of early HIV‐infected patients by combining voxel‐based morphometry (VBM) and tract‐based spatial statistics (TBSS). Materials and Methods Twenty‐six HIV and 26 control subjects enrolled in this study with 3D T 1 and diffusion‐tensor imaging acquired on a 3.0T Siemens scanner. Group differences in regional GM were assessed using VBM analysis, while differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and relative anisotropy (RD) of WM were evaluated using TBSS analysis. After that, interactions between GM changes and white matter alterations were investigated by using a correlation analysis. Results The HIV‐infected patients displayed decreased GM volume, mainly located in the bilateral frontal cortices, bilateral anterior cingulate cortex, and left supplementary motor area ( P < 0.05, false discovery rate‐corrected). Meanwhile, the patient group showed decreased FA in the genu of capsule callosum, body of capsule callosum, and bilateral anterior corona radiate ( P < 0.05, family wise error [FEW]‐corrected). Areas of increased MD, RD, and AD in HIV patients were more extensive and observed in most skeleton locations ( P < 0.05, FEW‐corrected). The interaction analysis in the patient group revealed that there were no significant correlations between GM changes and WM alterations ( P > 0.05). Conclusion Our results indicate that structural brain alterations occurred early in HIV‐infected patients. The current study may shed further light on the potential brain effects of HIV. J. Magn. Reson. Imaging 2016;43:1474–1483.