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Feasibility study of using intravoxel incoherent motion mri to detect parotid gland abnormalities in early‐stage Sjögren syndrome patients
Author(s) -
Su GuoYi,
Xu XiaoQuan,
Wang YanYan,
Hu Hao,
Shen Jie,
Hong XunNing,
Shi HaiBin,
Wu FeiYun
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25096
Subject(s) - intravoxel incoherent motion , medicine , magnetic resonance imaging , nuclear medicine , receiver operating characteristic , parotid gland , stage (stratigraphy) , perfusion , diffusion mri , radiology , pathology , paleontology , biology
Purpose To determine whether intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) could detect parotid gland abnormalities in Sjögren's syndrome (SS) patients who were not identified by conventional MRI. Materials and Methods Ten consecutive patients with clinically proven SS who were not identified by conventional MRI were assessed by IVIM MRI with a 3.0T MRI scanner. Quantitative parameters (tissue diffusivity, D; pseudodiffusion coefficient, D*; perfusion fraction, f) derived from IVIM MRI were compared between the SS group and healthy control group ( n = 15). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of each significant parameter. Results Excellent inter‐ and intrareader agreements were obtained during the measurement of D, f, and D* values (interreader, 0.980, 0.942, and 0.883; intrareader, 0.991, 0.952, and 0.896, respectively). All three parameters of the SS group were significantly higher than those of the healthy group (D, 1.049 ± 0.056 × 10 −3 mm 2 /s vs. 0.976 ± 0.116 × 10 −3 mm 2 /s, P = 0.012; D*, 20.410 ± 1.786 × 10 −3 mm 2 /s vs. 18.764 ± 2.433 × 10 −3 mm 2 /s, P = 0.013; f, 0.207 ± 0.003 vs. 0.182 ± 0.002, P = 0.004). ROC analysis showed that the f value had the best diagnostic performance (AUC, 0.712; Sensitivity, 0.80; Specificity, 0.57; Cutoff value, 0.185) in detecting the parotid gland abnormalities in early SS patients. Conclusion IVIM MRI detected parotid gland abnormalities in early‐stage SS patients. J. Magn. Reson. Imaging 2016;43:1455–1461.