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Automated detection of white matter and cortical lesions in early stages of multiple sclerosis
Author(s) -
Fartaria Mário João,
Bonnier Guillaume,
Roche Alexis,
Kober Tobias,
Meuli Reto,
Rotzinger David,
Frackowiak Richard,
Schluep Myriam,
Du Pasquier Renaud,
Thiran JeanPhilippe,
Krueger Gunnar,
Bach Cuadra Meritxell,
Granziera Cristina
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25095
Subject(s) - fluid attenuated inversion recovery , multiple sclerosis , white matter , nuclear medicine , lesion , magnetic resonance imaging , medicine , gradient echo , hyperintensity , radiology , pathology , psychiatry
Purpose To develop a method to automatically detect multiple sclerosis (MS) lesions, located both in white matter (WM) and in the cortex, in patients with low disability and early disease stage. Materials and Methods We developed a lesion detection method, based on the k‐nearest neighbor (k‐NN) technique, to detect lesions as small as 0.0036 mL. This method uses the image intensity information from up to four different 3D magnetic resonance imaging (MRI) sequences (magnetization‐prepared rapid gradient‐echo, MPRAGE; magnetization‐prepared two inversion‐contrast rapid gradient‐echo, MP2RAGE; 3D fluid‐attenuated inversion recovery, FLAIR; and 3D double‐inversion recovery, DIR), acquired on a 3T scanner. To these intensity features we added the information obtained by the spatial coordinates and tissue prior probabilities provided by the International Consortium for Brain Mapping (ICBM). Quantitative assessment was done in 39 early‐stage MS patients with a “leave‐one‐out” cross‐validation. Results The best lesion detection rate (DR) performance in WM was obtained using MP2RAGE, FLAIR, and DIR intensities (77% for lesions ≥0.0036 mL; 85% for lesions ≥0.005 mL). Similar results were obtained excluding the DIR intensity as well as when using only MPRAGE and FLAIR (DR = 75%, P = 0.5720). However, the combination of FLAIR with DIR and MP2RAGE appeared to be the best for detecting cortical lesions (DR = 62%), compared to the other combination of sequences ( P < 0.001). Conclusion For WM lesion detection, similar results were observed when only conventional clinical sequences (FLAIR, MPRAGE) were used compared to a combination of conventional and “advanced” sequences (MP2RAGE, DIR). Cortical lesion detection increased significantly when “advanced” sequences were used. J. Magn. Reson. Imaging 2015. J. Magn. Reson. Imaging 2016;43:1445–1454.