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Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T 1 relaxation time in the rotating frame
Author(s) -
Hu Genwen,
Zhang Xuhui,
Liang Wen,
Zhong Xing,
Chan Queenie,
Lin Xiaoying,
Lin Ting,
Li Yufa,
Quan Xianyue
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25084
Subject(s) - stage (stratigraphy) , receiver operating characteristic , carbon tetrachloride , fibrosis , effective diffusion coefficient , liver fibrosis , medicine , ccl4 , nuclear medicine , pathology , magnetic resonance imaging , nuclear magnetic resonance , chemistry , radiology , physics , biology , paleontology , organic chemistry
Purpose To explore the value of T 1 relaxation times in the rotating frame ( T 1 ρ or T 1 rho) for evaluating liver fibrosis stage, compared to apparent diffusion coefficients (ADCs). Materials and Methods Liver fibrosis in model rats ( n = 50) was produced by carbon tetrachloride (CCl 4 ) injection. Five rats died during the experiment. Surviving model rats ( n = 45) and controls ( n = 15) were subjected to 3.0T MRI and the ADCs (b‐values: 0, 800 s/mm 2 ) and T 1 ρ values were determined. Liver fibrosis stage (F0–F4) was defined based on METAVIR scoring. Nonparametric statistical methods and receiver operating characteristic (ROC) curve analyses were employed to determine diagnostic accuracy. Results Mean ADC and T 1 ρ associated negatively ( r = −0.732 P < 0.001) and positively ( r = 0.863 P < 0.001), respectively, with severity of fibrosis stage. Analysis of ROC curves for fibrosis staging showed that the area under the curve (AUC) for T 1 ρ (stage F0 vs. F1–F4 = 0.976, stage F0–F1 vs. F2–F4 = 0.920, stage F0–F2 vs. F3–F4 = 0.938, and stage F0–F3 vs. F4 = 0.931) was larger than that for ADCs (0.917, 0.924, 0.842, and 0.781, respectively). Conclusion ADC and T 1 ρ values correlate with liver fibrosis stage. The performance of the T 1 ρ parameter was superior to that of the ADC parameter in the differentiation of liver fibrosis stages in a CCl 4 rat model. J. Magn. Reson. Imaging 2016;43:1082–1089.