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Age‐related changes in aortic 3D blood flow velocities and wall shear stress: Implications for the identification of altered hemodynamics in patients with aortic valve disease
Author(s) -
van Ooij Pim,
Garcia Julio,
Potters Wouter V.,
Malaisrie S. Chris,
Collins Jeremy D.,
Carr James C.,
Markl Michael,
Barker Alex J.
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25081
Subject(s) - bicuspid aortic valve , hemodynamics , cardiology , medicine , aorta , aortic valve , blood flow , body surface area
Purpose To investigate age‐related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age‐matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). Materials and Methods 4D flow MRI (fields strengths = 1.5–3T; resolution = 2.2–3.9 × 1.7–2.6 × 2.2–4.0 mm 3 ; Venc = 150–250 cm/s; TE/TR/FA = 2.3–2.8/4.7–5.4msec/7–15°) was performed in 56 controls (age range: 19–78 years) and in two BAV patient groups each consisting of 10 subjects (group 1: 20–29 years, group 2: 52–57 years). Heat maps showing abnormal 3D velocity and WSS were created for the BAV patients by comparison with an age‐matched and with an unmatched control group. The fraction of the aorta exposed to abnormal velocity/WSS was calculated relative to the total aortic volume/surface. Results Significant inverse relationships between age and healthy velocity/WSS were found (R 2 = 0.32/0.39, P < 0.001). For BAV group 1, abnormally elevated velocity/WSS was overestimated when compared with older controls (51–60 years) than when correctly age‐matched (∼25 ± 14% vs. ∼8 ± 5%). For BAV group 2, abnormally decreased velocity/WSS was overestimated when compared with younger controls (21–30 years) than when correctly age‐matched (∼9 ± 7% vs. 1 ± 1%). Conclusion Significant correlations exist between age and peak systolic velocity and WSS. Therefore, robust age‐matching is important when creating abnormal 3D aortic velocity and WSS maps for patients with BAV. J. Magn. Reson. Imaging 2016;43:1239–1249.