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Reproducibility of cerebrovascular reactivity measures in children using BOLD MRI
Author(s) -
Leung Jackie,
Kim Junseok A.,
Kassner Andrea
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25063
Subject(s) - reproducibility , medicine , magnetic resonance imaging , radiology , nuclear medicine , mathematics , statistics
Purpose To evaluate the reproducibility of cerebrovascular reactivity (CVR) measurements acquired in children using magnetic resonance imaging (MRI) in combination with a computer‐controlled carbon dioxide (CO 2 ) stimulus. Materials and Methods Ten healthy children (age 16.1 ± 1.6 years) underwent CVR imaging on a 3T scanner using a blood‐oxygen level‐dependent (BOLD) MRI sequence. Targeted hypercapnia was induced during imaging with a CO 2 gas challenge delivered using a specialized gas sequencer (RespirAct). A total of four BOLD scans were performed over 2 separate days to test within‐day and between‐day consistency of the data. CVR values were computed by correlating the relative change in BOLD signal in response to the CO 2 stimulus delivered to the each subject. Results Intraclass correlation coefficients (ICCs) of within‐day values show highly reproducible measures in both the gray matter (ICC = 0.857, P < 0.001) and white matter (ICC = 0.895, P < 0.001). Relatively lower between‐day reproducibility was observed in both the gray matter (ICC = 0.776, P = 0.001) and white matter (ICC = 0.719, P = 0.004). Conclusion Using a computer‐controlled CO 2 stimulus, we have demonstrated the reliability of BOLD‐CVR measurements in pediatric subjects. Within‐day and between‐day metrics of reproducibility were comparable to adult data. J. Magn. Reson. Imaging 2016;43:1191–1195.