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Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma
Author(s) -
Bane Octavia,
Besa Cecilia,
Wagner Mathilde,
Oesingmann Niels,
Zhu Hongfa,
Fiel Maria Isabel,
Taouli Bachir
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25051
Subject(s) - carbogen , hccs , hepatocellular carcinoma , medicine , intraclass correlation , reproducibility , coefficient of variation , nuclear medicine , respiratory system , radiation therapy , chemistry , chromatography
Purpose To quantify baseline relaxation ratesR 2 *and R 1 in the abdomen, their changes after respiratory challenges, and their reproducibility in healthy volunteers and patients with hepatocellular carcinoma (HCC) at 1.5T and 3.0T. Materials and MethodsR 2 *measurements were acquired in the liver in 8 volunteers and 27 patients with 34 HCCs using multiechoT 2 *at baseline and after respiratory challenges with 100% oxygen (O 2 ) and carbogen (CB = 95%O 2 /5%CO 2 ). R 1 was measured at 1.5T in one volunteer and 21 patients with 23 HCCs. Test–retest coefficient of variation (CV) was assessed in 10 subjects. Intra‐ and interobserver variability ofR 2 *and R 1 measurements was assessed in 12 and 10 patients, respectively. Parameters for HCC, liver, and muscle were compared between baseline and after gas challenges. Results We observed thatR 2 *and R 1 imaging of HCCs with O 2 and CB is feasible and reproducible (test–retest CVR 2 * <15%/R 1 <5%; intra‐ and interobserver intraclass correlation coefficientR 2 * >0.88/R 1 >0.7 and CVR 2 * <7%/R 1 <3% at 1.5T).R 2 *measurements were observed to be less reproducible at 3.0T (CV<35%). There was a statistically significant decrease inR 2 *values in HCC before and after O 2 ( P = 0.02) and increase in R 1 after O 2 ( P = 0.004). CB had no significant effect ( PR 2 * = 0.47/R 1 = 0.278). ConclusionR 2 *measurements in HCC and liver parenchyma are more reproducible at 1.5T than at 3.0T, and with O 2 than with CB challenge. We observed a decrease inR 2 *and an increase in R 1 of HCCs from baseline in response to O 2 challenge, as expected with increased tissue and blood oxygenation. J. Magn. Reson. Imaging 2016;43:866–876