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Findings in pancreatic MRI associated with pancreatic fibrosis and HbA1c values
Author(s) -
Noda Yoshifumi,
Goshima Satoshi,
Tanaka Kaori,
Osada Shinji,
Tomita Hiroyuki,
Hara Akira,
Horikawa Yukio,
Takeda Jun,
Kajita Kimihiro,
Watanabe Haruo,
Kawada Hiroshi,
Kawai Nobuyuki,
Kanematsu Masayuki,
Bae Kyongtae T.
Publication year - 2016
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.25019
Subject(s) - medicine , magnetic resonance imaging , pancreas , effective diffusion coefficient , fibrosis , diffusion mri , liver fibrosis , nuclear medicine , gastroenterology , radiology
Purpose To evaluate the diagnostic performance of noncontrast‐enhanced magnetic resonance imaging (MRI) to grade pancreatic fibrosis and to assess hemoglobin (Hb) A1c values. Materials and Methods Twenty‐nine consecutive patients with pancreatic or biliary malignancy who underwent pancreatectomy were evaluated. Patients were classified into three groups: HbA1c < 5.7 (group 1), 5.7 ≤ HbA1c < 6.5 (group 2), and HbA1c ≥ 6.5 (group 3). MRI of the pancreas was performed using a 1.5T MR system. The pancreas‐to‐muscle signal intensity ratio (SIR) on in‐ and opposed‐phase T 1 ‐, T 2 ‐, and diffusion‐weighted images, as well as the apparent diffusion coefficient were calculated. MRI measurements, degrees of pancreatic fibrosis, and HbA1c values were compared using multiple regression analysis and Kruskal–Wallis test. Results The pancreatic fibrosis grade was negatively correlated with the SIR on in‐phase T 1 ‐weighted images ( r = –0.67, P = 0.0002). The pancreatic fibrosis grade and HbA1c value were negatively correlated with the SIR on opposed‐phase T 1 ‐weighted images ( r = –0.47, P = 0.019 and r = –0.51, P = 0.0089, respectively). SIRs on in‐ and opposed‐phase T 1 ‐weighted images were significantly lower in group 3 than in groups 1 and 2 ( P < 0.05). Conclusion The pancreas‐to‐muscle SIRs on in‐ and opposed‐phase T 1 ‐weighted images could be a potential biomarker for pancreatic fibrosis and elevated HbA1c values. J. MAGN. RESON. IMAGING 2016;43:680–687.