z-logo
Premium
Diffusion kurtosis imaging predicts neoadjuvant chemotherapy responses within 4 days in advanced nasopharyngeal carcinoma patients
Author(s) -
Chen Yunbin,
Ren Wang,
Zheng Dechun,
Zhong Jing,
Liu Xiangyi,
Yue Qiuyuan,
Liu Meng,
Xiao Youping,
Chen Weibo,
Chan Queenie,
Pan Jianji
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24910
Subject(s) - effective diffusion coefficient , medicine , nasopharyngeal carcinoma , kurtosis , receiver operating characteristic , diffusion mri , mann–whitney u test , nuclear medicine , chemotherapy , stage (stratigraphy) , radiology , magnetic resonance imaging , radiation therapy , paleontology , statistics , mathematics , biology
Purpose To explore the clinical value of diffusion kurtosis imaging (DKI) and monoexponential diffusion‐weighted imaging (DWI) for predicting early response to neoadjuvant chemotherapy (NAC) in patients with nasopharyngeal carcinoma (NPC). Materials and Methods Fifty‐nine patients with stage III‐IVb NPC underwent four 3.0T MR scans: prior to, and on the 4th, 21st, 42nd days after NAC initiation. The parameters of DKI (corrected diffusion coefficient, D; excess diffusion kurtosis coefficient, K) and monoexponential DWI (apparent diffusion coefficient, ADC) were obtained at the first three scans. Statistical methods included Student's t ‐test or Mann‐Whitney U ‐test, receiver operating characteristic (ROC) curve analyses and paired X 2 test. Results D (pre) in responders group (RG) was significantly lower than nonresponders group (NRG) (1.029 ± 0.033 vs. 1.184 ± 0.055, ×10 −3 mm 2 /s, P  = 0.020). ADC (day4) and ΔD (day4) were the most useful parameters of the two diffusional models to distinguish RG from NRG, respectively (area under the curve, 0.761 vs. 0.895). ΔD (day4) was more sensitive than ADC (day4) to predict treatment response to NAC ( P  = 0.006). Conclusion Both DKI and monoexponential DWI showed potential to predict treatment response to NAC prior to morphological change. DKI may be superior to monoexponential DWI for predicting early response to NAC in patients with locally advanced NPC. J. Magn. Reson. Imaging 2015;42:1354–1361.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here