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Rapid in vivo multicomponent T 2 mapping of human knee menisci
Author(s) -
Liu Fang,
Samsonov Alexey,
Wilson John J.,
Blankenbaker Donna G.,
Block Walter F.,
Kijowski Richard
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24901
Subject(s) - asymptomatic , medicine , t2 relaxation , knee joint , nuclear medicine , magnetic resonance imaging , radiology , surgery
Purpose To compare multicomponent T 2 parameters of menisci measured using Multicomponent Driven Equilibrium Single Pulse Observation of T 1 and T 2 (mcDESPOT) in asymptomatic volunteers and osteoarthritis (OA) patients with intact and torn menisci. Materials and Methods The prospective study was performed with Institutional Review Board approval and with all subjects signing written informed consent. mcDESPOT was performed on the knee joint of 12 asymptomatic volunteers and 14 patients with knee OA. Single‐component T 2 relaxation time ( T 2Single ), T 2 relaxation time of the fast relaxing water component ( T 2F ), and the slow relaxing water component ( T 2S ), and fraction of the fast relaxing water component (F F ) of the medial and lateral menisci were measured. Multivariate linear regression models were used to compare mcDESPOT parameters between normal menisci in asymptomatic volunteers, intact menisci in OA patients, and torn menisci in OA patients with adjustment for differences in age between subjects. Results The mean mcDESPOT parameters for normal menisci in asymptomatic volunteers, intact menisci in OA patients, and torn menisci in OA patients were respectively 16.1 msec, 18.8 msec, and 22.7 msec for T 2Single ; 9.0 msec, 10.0 msec, and 11.1 msec for T 2F ; 24.4 msec, 27.7 msec, and 31.4 msec for T 2S ; and 34%, 32%, 27% for F F . There were significant differences ( P < 0.05) in T 2Single , T 2F , T 2S , and F F between the three groups of menisci. Conclusion The menisci of OA patients had significantly higher T 2Single , T 2F , and T 2S and significantly lower F F than normal menisci in asymptomatic volunteers with greater changes in multicomponent T 2 parameters noted in torn than intact menisci in OA patients. J. Magn. Reson. Imaging 2015;42:1321–1328.