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Diagnostic accuracy of diffusion‐weighted MRI for differentiation of cervical cancer and benign cervical lesions at 3.0T: Comparison with routine MRI and dynamic contrast‐enhanced MRI
Author(s) -
Kuang Fei,
Yan Zhiping,
Li Huili,
Feng Hao
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24894
Subject(s) - medicine , magnetic resonance imaging , diffusion mri , radiology , effective diffusion coefficient , cervical cancer , dynamic contrast enhanced mri , nuclear medicine , cancer
Purpose To compare the diagnostic accuracy of routine magnetic resonance imaging (MRI) ( T 1 WI and T 2 WI), diffusion‐weighted MRI (DWI), and DCE‐MRI (dynamic contrast‐enhanced MRI) at 3.0T for differentiation of cervical cancer and benign cervical lesions. Materials and Methods A cohort of 75 cervical cancer patients, 26 cervical leiomyoma patients, 22 patients with cervical polyps consecutively underwent pelvic MRI scanning on a 3T MR unit. Two radiologists independently evaluated images at three imaging settings; routine MRI alone, DWI combined with routine MRI (DWI+routine MRI), and DCE‐MRI. The apparent diffusion coefficients (ADCs) were calculated from b 0, 600 s/mm 2 and b 0, 1000 s/mm 2 . Results DWI+routine MRI was significantly better than routine MRI and obtained high accuracy (0.95); the diagnostic performance was not significantly different between DWI+routine MRI and DCE‐MRI. Reader agreement was excellent for both DWI+routine MRI (κ, 0.90) and DCE‐MRI (κ, 0.92). The ADCs of cervical cancer were significantly lower than those of benign cervical lesions at both ADC maps ( P = 0.0001). The diagnostic accuracy was not different at both ADC maps ( P = 0.375). Conclusion For differentiation of cervical cancer and benign cervical lesions, unenhanced MRI with combined diffusion‐weighted and routine MRI (DWI+routine MRI) at 3T can provide accurate information and may be preferable to DCE. J. Magn. Reson. Imaging 2015. J. Magn. Reson. Imaging 2015;42:1094–1099.