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In vivo measurement reproducibility of femoral neck microarchitectural parameters derived from 3T MR images
Author(s) -
Hotca Alexandra,
Rajapakse Chamith S.,
Cheng Chen,
Honig Stephen,
Egol Kenneth,
Regatte Ravinder R.,
Saha Punam K.,
Chang Gregory
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24892
Subject(s) - reproducibility , medicine , intraclass correlation , nuclear medicine , coefficient of variation , femoral neck , osteoporosis , magnetic resonance imaging , radiology , pathology , mathematics , statistics
Purpose To evaluate the within‐day and between‐day measurement reproducibility of in vivo 3D MRI assessment of trabecular bone microarchitecture of the proximal femur. Materials and Methods This Health Insurance Portability and Accountability Act (HIPPA)‐compliant, Institutional Review Board (IRB)‐approved study was conducted on 11 healthy subjects (mean age = 57.4 ± 14.1 years) with written informed consent. All subjects underwent a 3T MRI hip scan in vivo (0.234 × 0.234 × 1.5 mm) at three timepoints: baseline, second scan same day (intrascan), and third scan 1 week later (interscan). We applied digital topological analysis and volumetric topological analysis to compute the following microarchitectural parameters within the femoral neck: total bone volume, bone volume fraction, markers of trabecular number (skeleton density), connectivity (junctions), plate‐like structure (surfaces), plate width, and trabecular thickness. Reproducibility was assessed using root‐mean‐square coefficient of variation (RMS‐CV) and intraclass correlation coefficient (ICC). Results The within‐day RMS‐CVs ranged from 2.3% to 7.8%, and the between‐day RMS‐CVs ranged from 4.0% to 7.3% across all parameters. The within‐day ICCs ranged from 0.931 to 0.989, and the between‐day ICCs ranged from 0.934 to 0.971 across all parameters. Conclusion These results demonstrate high reproducibility for trabecular bone microarchitecture measures derived from 3T MR images of the proximal femur. The measurement reproducibility is within a range suitable for clinical cross‐sectional and longitudinal studies in osteoporosis. J. Magn. Reson. Imaging 2015;42:1339–1345.