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Test–retest reliability of cerebral blood flow and blood oxygenation level‐dependent responses to hypercapnia and hyperoxia using dual‐echo pseudo‐continuous arterial spin labeling and step changes in the fractional composition of inspired gases
Author(s) -
Tancredi Felipe B.,
Lajoie Isabelle,
Hoge Richard D.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24878
Subject(s) - hypercapnia , cerebral blood flow , hyperoxia , reproducibility , medicine , anesthesia , arterial spin labeling , oxygenation , blood flow , blood oxygen level dependent , arterial blood , perfusion , nuclear medicine , cardiology , acidosis , magnetic resonance imaging , chemistry , lung , radiology , chromatography
Purpose To assess the reproducibility of blood oxygenation level‐dependent / cerebral blood flow (BOLD/CBF) responses to hypercapnia/hyperoxia using dual‐echo pseudo‐continuous arterial spin labeling (pCASL) and step changes in inspired doses. Materials and Methods Eight subjects were scanned twice, within 24 hours, using the same respiratory manipulation and imaging protocol. Imaging comprised a 5‐minute anatomical acquisition, allowing segmentation of the gray matter (GM) tissue for further analysis, and an 18‐minute pCASL functional scan. Hypercapnia/hyperoxia were induced by increasing the fraction of inspired CO 2 to 5% and inspired O 2 to 60%, alternately. Reproducibility of BOLD and CBF pCASL measures was assessed by computing the inter‐session coefficient of variation (CV) of the respective signals in GM. Results BOLD and CBF measures in GM were robust and consistent, yielding CV values below 10% for BOLD hypercapnic/hyperoxic responses (which averaged 1.9 ± 0.1% and 1.14 ± 0.02%) and below 20% for the CBF hypercapnic response (which averaged 35 ± 2 mL/min/100g). The CV for resting CBF was 3.5%. Conclusion It is possible to attain reproducible measures of the simultaneous BOLD and CBF responses to blood gases, within a reasonable scan time and with whole brain coverage, using a simple respiratory manipulation and dual‐echo pCASL. J. Magn. Reson. Imaging 2015;42:1144–1157.