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Multiparametric analysis of bone marrow in cancer patients using simultaneous PET/MR imaging: Correlation of fat fraction, diffusivity, metabolic activity, and anthropometric data
Author(s) -
Schraml Christina,
Schmid Marinus,
Gatidis Sergios,
Schmidt Holger,
Fougère Christian,
Nikolaou Konstantin,
Schwenzer Nina F.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24865
Subject(s) - nuclear medicine , medicine , effective diffusion coefficient , standardized uptake value , correlation , bone marrow , positron emission tomography , adipose tissue , correlation coefficient , pearson product moment correlation coefficient , magnetic resonance imaging , radiology , pathology , mathematics , statistics , geometry
Background To analyze the regional composition of bone marrow (BM) in correlation with metabolic activity and diffusivity using simultaneous positron emission tomography (PET)/MRI. Methods Retrospective analysis of 18F‐FDG‐PET/MR scans of 110 patients was performed. A three‐dimensional gradient‐echo sequence with Dixon‐based fat–water separation was used for fat quantification. Dixon images, diffusion‐weighted images (DWI) and 18F‐FDG‐PET were co‐registered. Mean values of fat fraction (FF), standardized uptake value (SUV), and apparent diffusion coefficient (ADC) of BM were measured in different anatomical regions. Correlation of FF, SUV, and ADC and association of BM fat content and metabolic activity with anthropometric data was analyzed (Pearson). BM fat content and metabolic activity was compared in patients with and without chemotherapy (t‐test). Results Regional differences in BM were found with highest fat content (93 ± 8%) and lowest ADC (0.22 ± 0.18 × 10 −3 mm 2 /s) in the peripheral skeleton and highest SUV in the spine (1.77 ± 0.6). There was a significant inverse correlation between FF and SUV (r = −0.73; P < 0.0001) and a significant inverse correlation between FF and ADC (r = −0.62; P < 0.0001). In patients with chemotherapy, a tendency to higher fat content and lower metabolic activity was observed in the proximal skeleton, although no statistical significance was reached. Conclusion BM shows distinct regional variations in FF, SUV, and ADC. The inverse correlation of FF and SUV in BM suggests that BM adipose tissue does not have a comparable high metabolic activity as brown adipose tissue. J. Magn. Reson. Imaging 2015;42:1048–1056.