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Multiparametric MRI in characterizing venous thrombi and pulmonary thromboemboli acquired from patients with pulmonary embolism
Author(s) -
Vidmar Jernej,
Kralj Eduard,
Bajd Franci,
Serša Igor
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24816
Subject(s) - medicine , thrombolysis , pulmonary embolism , effective diffusion coefficient , nuclear medicine , radiology , thrombus , magnetic resonance imaging , occlusion , cardiology , myocardial infarction
Background The structure of thrombi plays an important role in delaying reperfusion and re‐occlusion after intravenous thrombolysis and could influence the performance of mechanical thrombectomy devices. This study aims to distinguish various thrombi groups based on their T 2 and apparent diffusion coefficient (ADC) properties. Methods 26 venous thrombi (VT), 28 acute (aPTE) and 18 chronic pulmonary thromboemboli (cPTE) and 18 sedimented clots (SC) were scanned by a three‐dimensional T 1 ‐weighted spin‐echo sequence and by T 2 and ADC mapping. Immunohistochemical analysis was used as a reference. Differences in the ADC, T 2 and paired ADC‐ T 2 distributions between the various thrombi group pairs were analyzed by standard statistics as well as by overlap integrals. Results Paired ADC‐ T 2 distribution enabled the most efficient discrimination of structural changes between pairs of thrombi. For thrombi pairs VT‐cPTE, VT‐SC, aPTE‐cPTE, aPTE‐SC, cPTE‐SC differences were statistically significant ( p ADC , p T 2 , p ADC‐T 2 < 0.05) and the values of the overlap integrals were low ( OI ADC ≤ 0.505, OI T2 ≤ 0.823, OI ADC‐T2 ≤ 0.379). Least efficient was the structural discrimination for the VT‐aPTE pair ( p T 2 = 0.877, OI T2 = 0.940). Conclusion Multiparametric MRI is an efficient method for discriminating different thrombi groups at various stages of organization. J. Magn. Reson. Imaging 2015;42:354–361.