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Comparison of noncontrast MRI magnetization transfer and T 2 ‐Weighted signal intensity ratios for detection of bowel wall fibrosis in a Crohn's disease animal model
Author(s) -
Dillman Jonathan R.,
Swanson Scott D.,
Johnson Laura A.,
Moons David S.,
Adler Jeremy,
Stidham Ryan W.,
Higgins Peter D.R.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24815
Subject(s) - magnetic resonance imaging , magnetization transfer , nuclear medicine , medicine , enema , inflammatory bowel disease , gastroenterology , intensity (physics) , nuclear magnetic resonance , radiology , physics , disease , quantum mechanics
Purpose To compare the abilities of magnetization transfer magnetic resonance imaging (MT‐MRI) and T 2 ‐weighted signal intensity ( T 2 WSI) ratios to detect intestinal fibrosis in a Crohn's disease animal model. Materials and Methods Ten rats ("Group 1") received one trinitrobenzenesulfonic acid enema to induce acute colonic inflammation, while 10 additional animals ("Group 2") received multiple enemas to induce colonic inflammation and fibrosis. Gradient recalled‐echo MT‐MRI (5 and 10 kHz off‐resonance) and T 2 ‐weighted spin‐echo imaging were performed 2 days after the last enema. MT ratios (MTR) and T 2 WSI ratios were calculated in the area of greatest colonic thickening. Bowel wall MTR, bowel wall MTR normalized to paraspinous muscle MTR ("normalized MTR"), and T 2 WSI ratios were compared between animal groups using Student's t ‐test. Results At 10 kHz off‐resonance, mean bowel wall MTR for Group 1 was 24.8 ± 3.1% vs. 30.3 ± 3.2% for Group 2 ( P = 0.001). Mean normalized MTR was 0.45 ± 0.05 for Group 1 and 0.58 ± 0.08 for Group 2 ( P = 0.0003). At 5 kHz off‐resonance, mean bowel wall MTR for Group 1 was 34.7 ± 5.2% vs. 40.3 ± 3.6% for Group 2 ( P = 0.015). Mean normalized MTR was 0.53 ± 0.08 for Group 1 and 0.64 ± 0.07 for Group 2 ( P = 0.003). Mean T 2 WSI ratio was 5.32 ± 0.98 for Group 1 and 3.01 ± 0.66 for group 2 ( P < 0.0001). Mean T 2 WSI ratio/MTR (10 kHz off‐resonance) was 12.06 ± 2.70 for Group 1 and 5.22 ± 1.29 for Group 2 ( P < 0.0001), with an ROC c‐statistic of 0.98. Conclusion MTR and T 2 WSI ratios detect bowel wall fibrosis in a Crohn's disease animal model. J. Magn. Reson. Imaging 2015;42:801–810.