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Relationship between intravoxel incoherent motion diffusion‐weighted MRI and dynamic contrast‐enhanced MRI in tissue perfusion of cervical cancers
Author(s) -
Lee Elaine Yuen Phin,
Hui Edward Sai Kam,
Chan Karen Kar Loen,
Tse Ka Yu,
Kwong Wai Kay,
Chang Tien Yee,
Chan Queenie,
Khong PekLan
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24808
Subject(s) - intravoxel incoherent motion , perfusion , magnetic resonance imaging , nuclear medicine , dynamic contrast enhanced mri , medicine , effective diffusion coefficient , diffusion mri , nuclear magnetic resonance , radiology , physics
Purpose To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion‐weighted magnetic resonance imaging (MRI) and dynamic contrast‐enhanced MRI (DCE‐MRI) in cervical cancer perfusion. Materials and Methods Prospective newly diagnosed cervical cancer patients underwent diffusion‐weighted MRI (13 b ‐values: 1–1000 s/mm 2 ) and DCE‐MRI. The IVIM perfusion parameters, perfusion fraction ( f ), pseudodiffusion coefficient (D*), and flow‐related parameter ( f D*), were derived from a biexponential decay model. DCE‐MRI was analyzed with a pharmacokinetic model and signal‐time curve to derive the amplitude factor ( A ), estimated volume transfer constant between blood plasma, and the extravascular extracellular space ( est K trans ), maximum relative enhancement (MaxRE), and area under the signal‐time curve (AUC). Spearman's rank correlation coefficient ( r ) evaluated the correlative relationships. Results The f = 13.51% ± 1.76%, D* = 71.72 ± 7.55 × 10 −3 mm 2 /s, f D* = 9.64 ± 1.28 × 10 −3 mm 2 /s, A = 1.41 ± 0.43, est K trans = 0.19 ± 0.06 s −1 , MaxRE of 120.02 ± 21.07%, and AUC 212,393 ± 54,423 was found in 25 cervical cancer patients. Statistically significant positive correlations were found between f D* and est K trans ( r = 0.42, P = 0.038), f D* and A ( r = 0.50, P = 0.011), f D* and MaxRE ( r = 0.52, P = 0.008), f and AUC ( r = 0.58, P = 0.003). Conclusion: The IVIM perfusion parameters showed moderate to good correlations with quantitative and semiquantitative perfusion parameters derived from DCE‐MRI in cervical cancer. J. Magn. Reson. Imaging 2014. J. Magn. Reson. Imaging 2015;42:454–459.